POST-INFLAMMATORY COMPLICATIONS IN UVEITIS

葡萄膜炎的炎症后并发症

• 批准号: 3918824
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918824
• 关键词: cell membrane; choroid uvea; glia; gliosis; histochemistry /cytochemistry; histopathology; human tissue; immunochemistry; inflammation; medical complication; retina; scars; uveitis; visual photoreceptor

Complications of post-inflammation in uveitis patients includes destruction of photoreceptors, gliosis, choroidal scar, and formations of cyclitic membrane, snowbanking and preretinal membrane. Pos-inflammatory membrane composition ma play an important role in the cause of complications associated with uveitis. In this study, eyes enucleated from patients with end stages of chronic anterior uveitis (formation of cyclitic membrane), pars planitis (formation of preretinal membrane) were evaluated immunohistochemically. Glial cells and proliferating Muller cells were the major cellular components in these membranes. Basement membrane-like components and new collagens were the major extracellular membrane components.

葡萄膜炎患者炎症后的并发症包括 光感受器破坏、神经胶质增生、脉络膜瘢痕， 睫状体膜、雪堆和视网膜前膜的形成 膜的 炎症后膜成分可能起作用， 重要作用的原因相关的并发症 色素层炎。 在这项研究中， 慢性前葡萄膜炎的阶段（形成环状 膜），睫状体平坦部（视网膜前膜形成）， 化学评价。 胶质细胞和增殖 苗勒细胞是这些膜的主要细胞成分。 基底膜样成分和新胶原是主要的 细胞外膜成分。