EXPRESSION OF CLASS II ANTIGENS IN OCULAR INFLAMMATORY DISORDERS

II 类抗原在眼部炎症性疾病中的表达

• 批准号: 3965394
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965394
• 关键词: autoimmune disorder; gene expression; histochemistry /cytochemistry; histocompatibility antigens; inflammation; retinitis pigmentosa; uvea ciliary body; uveitis

Expression of class II antigens on ocular nonlymphoid cells was evaluated in experimental autoimmune uveoretinitis (EAU) by the immunoperoxidase technique. Class II antigens on nonlymphoid cells were not detected from normal rats. However, these antigens were detected on the retinal pigment epithelia and ciliary body epithelia a few days prior to the development of clinical and histopathological EAU. Ia antigen was noted on the retinal vascular endothelia at the onset of cellular infiltration in the retina, and appeared on the corneal keratocytes and scleral fibroblasts after the early stage of clinical EAU. The study demonstrates that during the course of EAU the ocular nonlymphoid cells can be activated to express class II antigens. This antigen expression may be important in the initiation and perpetuation of immune reactivity in the eye.

评价眼非淋巴样细胞上II类抗原的表达 在实验性自身免疫性葡萄膜视网膜炎（EAU）的免疫过氧化物酶 法 非淋巴样细胞上的II类抗原未从 正常老鼠 然而，在视网膜色素上检测到这些抗原， 上皮细胞和睫状体上皮细胞的发展前几天， 临床和组织病理学EAU。 在视网膜上发现Ia抗原 视网膜中细胞浸润开始时的血管内皮， 并出现在角膜基质细胞和巩膜成纤维细胞上， 临床早期EAU。 研究表明，在EAU的过程中，眼非淋巴样 细胞可被激活以表达II类抗原。 该抗原 表达可能在免疫系统的启动和持续中是重要的， 眼睛的反应。