IMMUNOPATHOLOGY IN THE EYES WITH EXPERIMENTAL AUTOIMMUNE UVEITIS

实验性自身免疫性葡萄膜炎的眼部免疫病理学

• 批准号: 3941666
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941666
• 关键词: T lymphocyte; autoimmune disorder; cyclosporines; dexamethasone; eye; eye pharmacology; helper T lymphocyte; histochemistry /cytochemistry; histocompatibility antigens; immunochemistry; immunosuppression; inflammation; major histocompatibility complex; uveitis

Identity and topographic localization of immunocompetent cells and alteration of surface marker on ocular resident cells in rodents with experimental autoimmune uveoretinitis by active immunization or adoptive transfer were analyzed by immunohistochemical studies. The lymphocyte population at the inflammatory sites was found to change markedly during the course of disease. In the early stage, T-helper/inducers are the predominant cells in the eye. A relative increase of T- suppressor/cytotoxic cells in the late stage were observed. Expression of major histocompatibility complex class II antigens on ocular resident cells such as RPE, retinal endothelium, keratocytes, fibroblast and ciliary epithelium was observed in different models of EAU. This antigen expression may play a certain role in the pathogenesis of EAU. Both infiltrating and alteration of class II antigens cell subpopulation can be modulated by cyclosporine and dexamethosone treatment.

免疫活性细胞的定位与鉴定 和眼球驻留细胞表面标志的改变 实验性自身免疫性葡萄膜视网膜炎的啮齿类动物 对免疫或采用转移进行了分析 免疫组织化学研究。外周血中淋巴细胞数量 炎症部位在发病过程中发生明显变化。 病程。在早期阶段，T-Helper/Inducers是 眼内的优势细胞。T-的相对增加 晚期可见抑制性/细胞毒性细胞。 主要组织相容性复合体II类抗原的表达 在视网膜色素上皮、视网膜内皮细胞、 角膜基质细胞、成纤维细胞和睫状体上皮细胞。 不同型号的EAU。这种抗原表达可能起到了 在EAU的发病机制中有一定的作用。无论是渗透还是渗透 II类抗原细胞亚群的改变是可以调节的 用环孢素和地塞米松治疗。