IMMUNOPATHOLOGY OF OCULAR ONCHOCERCIASIS

眼盘尾丝虫病的免疫病理学

• 批准号: 3965397
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965397
• 关键词: T lymphocyte; antiantibody; communicable disease diagnosis; conjunctiva; eye circulation; eye disorder diagnosis; eye infections; fibroblasts; gene expression; helminthic antigen; histocompatibility antigens; human tissue; immunopathology; inflammation; iris; onchocerciasis; suppressor T lymphocyte; vascular endothelium

Ocular specimens and sera from 12 patients with onchocerciasis and 10 controls were studied. A mild to moderate chronic inflammatory cellular infiltration was present in the conjunctiva of the onchocerciasis patients. T-lymphocytes were the predominant inflammatory cells with the T-suppressor subset being significantly increased in the onchocerciasis patients when compared to controls. In the onchoceriasis patients, the nonlymphoid cells in the conjunctiva and iris, such as vascular endothelia, pericytes and fibroblasts, showed an increase in expression of class II antigens. The anti-onchocerca Volvulus antibodies in the sera and aqueous humor were significantly highter in the patients compared to the controls. These findings suggest that T-cells are important in the ocular immune response to onchocerca and that expression of class II antigens on nonlymphoid cells and the humoral factors may all play a critical role in ocular onchocerciasis.

12例盘尾丝虫病患者的眼部标本和血清