SYMPATHETIC OPHTHALMIA--IMMUNOPATHOLOGICAL FINDINGS

交感性眼炎--免疫病理学发现

• 批准号: 3941667
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941667
• 关键词: B lymphocyte; Freund's adjuvant; T lymphocyte; autoimmune disorder; eye disorder diagnosis; histochemistry /cytochemistry; histopathology; human tissue; immunochemistry; macrophage

Immunocompetent cells and ocular resident cells in the ocular tissues from patients with a clinical diagnosis of sympathetic ophthalmia were examined using the immunohistochemical technique. The choroidal infiltrates were composed primarily of T-lymphocytes. Different amounts of macrophages and B lymphocytes were present in each case. A varied spectrum of immunopathological and histopathological findings may occur in clinically diagnosed sympathetic ophthalmia. The immunopathology resembles EAU induced by retinal soluble model. Exposure of uveal tissue outside the eye and adjuvant effect may be important in the pathogenesis of this disease in humans.

眼内的免疫活性细胞和眼常驻细胞 来自临床诊断为交感神经病的患者的组织 使用免疫组织化学检查眼炎 技术。 脉络膜浸润物主要由 T淋巴细胞。 不同数量的巨噬细胞和B 每个病例中都存在淋巴细胞。 各种各样的 免疫病理学和组织病理学发现可能发生在 临床诊断为交感性眼炎。 这 免疫病理学类似于视网膜可溶性诱导的 EAU 模型。 葡萄膜组织暴露于眼外及佐剂 效应可能在该疾病的发病机制中起重要作用 人类。