IMMUNOPATHOLOGY OF OCULAR ONCHOCERCIASIS AND OTHER PARASITIC DISEASE

眼盘尾丝虫病和其他寄生虫病的免疫病理学

• 批准号: 3941668
• 负责人: C-C CHAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941668
• 关键词: T lymphocyte; antiantibody; autoimmune disorder; communicable disease diagnosis; conjunctiva; eye disorder diagnosis; eye infections; fibroblasts; helminthic antigen; histocompatibility antigens; human tissue; immunopathology; inflammation; iris; onchocerciasis; retina degeneration; suppressor T lymphocyte; vascular endothelium

Ocular specimens and sera from 12 patients with onchocerciasis and 10 controls were studied. A mild to moderate chronic inflammatory cellular infiltration was present in the conjunctiva of the onchocerciasis patients. T-lymphocytes were the predominant inflammatory cells with the T-suppressor subset being significantly increased in the onchocerciasis patients when compared to controls. In the onchocerciasis patients, the nonlymphoid cells in the conjunctiva and iris, such as vascular endothelia, pericytes and fibroblasts, showed an increase in expression of class II antigens. The anti-onchocerca Volvulus antibodies in the sera and aqueous humor were significantly higher in the patients compared to the controls. These findings suggest that T-cells are important in the ocular immune response to onchocerca and that expression of class II antigens on nonlymphoid cells and the humoral factors may all play a critical role in ocular onchocerciasis. Using the indirect immunoperoxidase method, autoimmune antibodies against outer segments of photoreceptors and inner neural layers of retina were identified in sera and ocular fluids from patients with onchocerciasis. These antibodies could not be absorbed by S-Ag nor IRBP. They may play a role in the retinal degeneration in onchocerciasis.

12例盘尾丝虫病患者的眼球标本和血清 并对10名对照进行研究。轻度至中度慢性 结膜内有炎性细胞浸润。 盘尾丝虫病患者。T淋巴细胞是 以T抑制亚群为主的炎性细胞 在盘尾丝虫病患者中显著增加 与对照组相比。在盘尾丝虫病患者中， 结膜和虹膜中的非淋巴样细胞，如血管 内皮细胞、周细胞和成纤维细胞，表现出增加 II类抗原的表达。抗蜗牛胸膜吸虫抗体 血清和房水中的抗体显著高于 在患者和对照组之间进行比较。这些发现表明 T细胞在眼部免疫反应中起重要作用 盘尾丝虫及其第二类抗原的表达 非淋巴样细胞和体液因素都可能起到关键作用 在眼部盘尾丝虫病中的作用。使用间接的 免疫过氧化物酶法抗外膜自身免疫抗体 视网膜的光感受器和内神经层的节段 从患者的血清和眼液中鉴定出 盘尾丝虫病。这些抗体不能被S-Ag吸收。 IRBP也不行。它们可能在视网膜退行性变中起作用 盘尾丝虫病。