Molecular Mechanisms of Fibrosis: From Bench to Bedside

纤维化的分子机制：从实验室到临床

• 批准号: 7223388
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7223388
• 关键词: Affect; Architecture; Area; Bone Marrow; California; Cardiac; Cerebrum; Chronic; Cities; Clinical; Clinical Trials Design; Connective Tissue; Deposition; Development; Disease; Disease regression; Drug Industry; Elements; Endopeptidases; Epithelial; Experimental Models; Extracellular Matrix; Fibrosis; Goals; Graft Rejection; Growth Factor; Hamman-Rich syndrome; Heart Diseases; Human; Individual; Inflammation; Inflammatory; Interstitial Lung Diseases; Kidney; Kidney Diseases; Knowledge; Liver; Liver Cirrhosis; Lung; Lymphocyte; Malignant Neoplasms; Mesenchymal; Modeling; Molecular; Morbidity - disease rate; Neoplasm Metastasis; Normal tissue morphology; Numbers; Pathway interactions; Peptide Hydrolases; Peripheral Vascular Diseases; Pharmaceutical Preparations; Preclinical Drug Evaluation; Production; Progressive Disease; Research Personnel; Role; Skin; Stimulus; System; Systemic Scleroderma; Tissues; Transplant Recipients; Vascular Diseases; base; bench to bedside; body system; cytokine; fibrogenesis; member; monocyte; mortality; novel; research clinical testing; symposium

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposium entitled "Molecular Mechanisms of Fibrosis: From Bench to Bedside", which will be held in Tahoe City, California from March 11-15, 2007. Fibrosis affects nearly all tissues and organ systems. Diseases in which fibrosis is a major cause of morbidity and mortality include the interstitial lung diseases, liver cirrhosis, kidney disease, heart disease, and systemic sclerosis, among others. Fibrotic tissue remodeling can also influence cancer metastasis and accelerate chronic graft rejection in transplant recipients. Current treatments for fibrotic disorders target the inflammatory cascade, but they have been widely unsuccessful, largely because the mechanisms that are involved in fibrogenesis are believed to be distinct from those involved in inflammation. Because mechanistic studies are difficult to carry out in humans, numerous experimental models have been developed over the past few years to dissect the immunological and molecular mechanisms of fibrosis. The first of new therapies based on these models are just beginning to approach clinical testing. The goal of this meeting is to bring together academic researchers, clinicians, and members of the pharmaceutical industry to discuss the most recent advances in the field and to identify common mechanistic themes of tissue fibrogenesis in various tissue systems. By bringing together a diverse group of researchers, the meeting will provide a more integrated perspective from basic disease mechanisms through to the more pragmatic challenges of clinical trial design in chronic progressive disease.

描述（由申请人提供）： 本提案旨在请求支持将于2007年3月11-15日在加州的太浩城举行的名为“纤维化的分子机制：从实验室到床边”的Keystone研讨会。纤维化影响几乎所有的组织和器官系统。其中纤维化是发病率和死亡率的主要原因的疾病包括间质性肺病、肝硬化、肾病、心脏病和系统性硬化症等。纤维化组织重塑也可影响癌症转移并加速移植受者的慢性移植物排斥。目前纤维化疾病的治疗靶向炎症级联反应，但它们普遍不成功，主要是因为认为参与纤维化的机制与参与炎症的机制不同。由于机制研究很难在人体中进行，因此在过去几年中开发了许多实验模型来剖析纤维化的免疫和分子机制。基于这些模型的第一种新疗法刚刚开始接近临床测试。本次会议的目标是汇集学术研究人员，临床医生和制药行业的成员，讨论该领域的最新进展，并确定各种组织系统中组织纤维化的共同机制主题。通过将不同的研究人员聚集在一起，会议将提供一个更综合的视角，从基本的疾病机制到慢性进展性疾病临床试验设计的更务实的挑战。