The Transient Receptor Potential Ion Channel Superfamily

描述（由申请人提供）：本提案旨在请求对将于2007年9月18日至23日在科罗拉多布雷肯里奇举行的题为“瞬时受体电位离子通道超家族”的Keystone研讨会会议的支持。近年来，TRP通道生物学的知识以惊人的速度增长。现在已知这些通道以两种一般方式调节：通过物理扰动（即，温度、机械）或通过经典的信号转导级联（最常见的是磷脂酶）。此外，已知TRP通道的突变是许多遗传性疾病的基础，包括粘脂沉积症和多囊肾病。然而，关于许多TRP的激活和调节机制存在很大争议，特别是那些被认为参与了长期难以捉摸的存储操作通道机制的TRP。本次研讨会将突出TRP的结构，功能，调节和药理学的当前知识，特别是关于当前的争议。此外，TRP在疾病中的作用将得到解决，包括通过了解其调节来治疗疾病的潜力，以及通过设计治疗药物来改变其行为。瞬时受体电位（TRP）离子通道正在成为药物干预的潜在有效靶点。对TRP通道机制和功能的理解将为寻求新的治疗策略以解决许多重要疾病带来机会。

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "The Transient Receptor Potential Ion Channel Superfamily", which will be held in Breckenridge, Colorado from September 18-23, 2007. In recent years, knowledge of TRP channel biology has increased at a tremendous pace. These channels are now known to be regulated in two general ways: by physical perturbations (i.e., temperature, mechanical) or by classical signal transduction cascades (most commonly phospholipases). In addition, mutations in TRP channels are known to be the basis for a number of inherited diseases, including mucolipidosis and polycystic kidney disease. However, there is a great deal of controversy regarding the mechanisms of activation and regulation of many TRPs, especially those thought to be involved in the long elusive mechanism of store-operated channels. This symposium will highlight current knowledge of structure, function, regulation and pharmacology of the TRPs, especially with regard to current controversies. Additionally, the roles of TRPs in diseases will be addressed, including the potential for treating diseases through knowledge of their regulation, and through design of therapeutic agents to modify their behavior. Transient Receptor Potential (TRP) ion channels are emerging as potentially fruitful targets for pharmacological intervention. An understanding of TRP channel mechanisms and functions will result in opportunities to pursue novel therapeutic strategies to address a number of important diseases.