PHARMACOKINETICS AND TOLERABILITY STUDY FOR MERCK COMPOUND

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肥胖现在被认为是一种世界性的流行病，它是由高热量饮食和缺乏适当锻炼引起的。在过去的十年里，已经发现了许多参与调节食物摄入量和能量消耗的新系统。针对这些系统的药物可能是治疗肥胖症和/或糖尿病的有用疗法。这项研究的目的很简单，就是确定一种新型默克化合物的药代动力学和耐受性研究。在这项研究中，我们使用了6只恒河猴，这些猕猴是通过慢性静脉注射维持的。使用旋转系绳系统的导尿管。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is now considered a worldwide epidemic that is caused by consuming calorically dense diets and a lack of proper exercise. In the past decade there have been numerous novel systems that have been discovered that are involved in the regulation of food intake and energy expenditure. Pharmaceuticals that target these systems may be useful therapeutics for the treatment of obesity and/or diabetes. This study had the simple goal to determine the pharmacokinetics and tolerability study for a novel Merck compound. For this study we used 6 rhesus macaques that were maintained on chronic i.v. catheters using the swivel tether system.