PHARMACOKINETICS AND TOLERABILITY STUDY FOR MERCK COMPOUND

MERCK 化合物的药代动力学和耐受性研究

• 批准号: 7561966
• 负责人: KEVIN L GROVE
• 金额: $ 11.39万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561966
• 关键词: Catheters; Chronic; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diet; Drug Kinetics; Energy Metabolism; Epidemic; Exercise; Food Intake Regulation; Funding; Goals; Grant; Institution; Macaca mulatta; Obesity; Pharmacologic Substance; Research; Research Personnel; Resources; Source; System; Therapeutic; United States National Institutes of Health; novel; obesity treatment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is now considered a worldwide epidemic that is caused by consuming calorically dense diets and a lack of proper exercise. In the past decade there have been numerous novel systems that have been discovered that are involved in the regulation of food intake and energy expenditure. Pharmaceuticals that target these systems may be useful therapeutics for the treatment of obesity and/or diabetes. This study had the simple goal to determine the pharmacokinetics and tolerability study for a novel Merck compound. For this study we used 6 rhesus macaques that were maintained on chronic i.v. catheters using the swivel tether system.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肥胖现在被认为是一种世界性的流行病，是由消耗高热量的饮食和缺乏适当的锻炼引起的。 在过去的十年中，已经发现了许多新的系统，这些系统参与了食物摄入和能量消耗的调节。 靶向这些系统的药物可以是用于治疗肥胖症和/或糖尿病的有用治疗剂。 本研究的简单目标是确定新型默克化合物的药代动力学和耐受性研究。对于本研究，我们使用了6只恒河猴，使用旋转系绳系统将其维持在慢性静脉内导管上。