Neurodegenerative Diseases: New Insights and Therapeutic Opportunities

摘要 请求支持题为神经退行性疾病：新见解的Keystone研讨会 和治疗机会，由Valina L.Dawson博士、Joseph W.Lewcock博士和Fred H.Gage博士组织。 大会将于2019年6月16日至20日在科罗拉多州的Keystone举行。 全球神经退行性疾病的负担令人震惊，并以惊人的速度增长 人口老龄化。而阿尔茨海默氏症和相关痴呆症，以及帕金森氏症和 相关的障碍，占大多数的困扰，也有不常见的，但同样 毁灭性的疾病。技术和概念上的进步正在揭示疾病的机制并提供 新的治疗机会。错误折叠的蛋白质被认为是 神经退行性疾病，但最近有一种认识到，这些错误折叠的蛋白质可能作为 种子是正常蛋白质错误折叠的模板，这些种子的传播可能是疾病的基础 这些种子可能有不同的毒力。生物物理 对这些蛋白质的分析揭示了这些蛋白质内在的相变和液体分离的作用 无序的蛋白质。突触丢失是神经退行性变的一个重要特征，它可能发生在很久以前 神经元丢失，但在疾病表现和功能丧失方面至关重要。神经胶质细胞与免疫 激活会导致神经退行性变和突触丢失，如果 疾病过程是要调和或停止的。这次会议的目的是讨论知识的现状。 在这些新兴领域并提供对这些主题的高级讨论；互动的机会 来自不同研究领域的科学家之间的合作将促进新的合作，这可能会导致新的 为应对即将到来的危机提供治疗机会，并为患有 神经退行性疾病。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neurodegenerative Diseases: New Insights and Therapeutic Opportunities, organized by Drs. Valina L. Dawson, Joseph W. Lewcock and Fred H. Gage. The conference will be held in Keystone, Colorado from June 16-20, 2019. The global burden of neurodegenerative disease is staggering and growing at an alarming rate as the population ages. While Alzheimer's disease and related dementias, as well as, Parkinson's disease and related disorders, account for the majority of those afflicted, there are also less common but equally devastating diseases. Technical and conceptual advances are revealing disease mechanisms and providing new therapeutic opportunities. Misfolded proteins have been understood to be at the center of neurodegenerative diseases but recently there is an appreciation that these misfolded proteins may serve as seeds to template the misfolding of normal proteins, that transmission of these seeds may underlie disease progression, and that there may be different strains of these seeds with differential toxicities. Biophysical analysis of these proteins reveals a role for phase transition and liquid demixing of these intrinsically disordered proteins. Synaptic loss is an important feature of neurodegeneration which may occur long before neuronal loss, but be critically important in disease presentation and loss of function. Glia and immune activation contribute to neurodegeneration and synaptic loss, and must be understood and controlled if the disease process is to be tempered or stopped. This conference aims to address the current state of knowledge in these emerging area and to provide advanced discussion of these topics; the opportunity for interaction between scientists from different fields of research will foster new collaborations that may lead to new therapeutic opportunities to combat the coming crisis and provide medical care for those suffering from neurodegenerative diseases.