B Cell Renaissance: Epigenetics, Regulation and Immunotherapy

摘要 请求支持题为B细胞复兴：表观遗传学的Keystone研讨会， 调节和免疫疗法，由Paolo Casali博士、Nicole Baumgarth博士、Meinrad Busslinger博士和 伊丽莎白·利德贝特。大会将于2019年3月1日至5日在加拿大艾伯塔省班夫举行。 这次会议将汇聚B细胞生物学的专家，讨论B细胞的最新进展 研究从最初的发展到成熟，包括效应器或记忆的发展，直到末期 差异化。最近这些B细胞研究的结果正引导研究人员变得更有鉴赏力 分子变化的重要性，包括表观遗传标记、修饰和控制因素 并调节B细胞的发育和分化，以及影响功能的调节力 B细胞的路径。B细胞通过生发中心和胞外分化途径的复杂性。 初级淋巴器官中的滤泡病灶，以及不同次级淋巴中的新相互作用 组织，也正在对老鼠和人类进行深入的研究。B细胞与淋巴样细胞的相互作用 各种环境中的非淋巴样细胞和分泌因子将在会议上讨论。 这将有助于阐明影响并最终决定每一项贡献的众多因素 独特的B细胞亚群，可用于动态平衡、免疫防御或免疫病理。了解哪些驱动因素 影响B细胞分化和功能将使精准利用这些关键因素来优化 B细胞及其抗体在自身免疫性疾病、感染和癌症中的免疫治疗作用

ABSTRACT Support is requested for a Keystone Symposia conference entitled B Cell Renaissance: Epigenetics, Regulation and Immunotherapy, organized by Drs. Paolo Casali, Nicole Baumgarth, Meinrad Busslinger and Elizabeth Leadbetter. The conference will be held in Banff, Alberta Canada from March 1-5, 2019. This conference will bring together experts in B cell biology to discuss the most recent advances in B cell research from initial development, through maturation, including effector or memory development, until terminal differentiation. The results of these recent B cells studies are guiding researchers to become more appreciative of the importance of the molecular changes, including epigenetic marks, modifications and factors that control and modulate B cell development and differentiation as well as the regulatory forces which influence functional paths of B cells. The complexities of B cell differentiation pathways through germinal centers and extra- follicular foci in primary lymphoid organs, in addition to novel interactions in diverse secondary lymphoid tissues, are also under intense study in both mice and humans. The interactions of B cells with lymphoid cells, non-lymphoid cells, and secreted factors in a myriad of environments will be covered in conference sessions. This will help elucidate the numerous factors which influence and ultimately dictate the contribution of each unique B cell subset to homeostasis, immune defense or immunopathology. Understanding the drivers which influence B cell differentiation and function will enable precise harnessing of these key elements to optimize the immuno-therapeutic effect of B cells and their antibodies in autoimmune disease, infection, and cancer.