HIV Pathogenesis and Cure

摘要 请求为题为《艾滋病毒的发病和治疗》的Keystone研讨会提供支助，由 Robert F.Siliciano博士、Carine M.Van Lint博士和Romas Geleziunas博士。会议将在Keystone举行， 科罗拉多州，2020年3月22日至26日。 人类免疫缺陷病毒1型(HIV)是一种具有很高死亡率的全球大流行的原因 到目前为止，估计有3500万人死亡。此外，另有3700万人目前与 感染艾滋病毒，很可能死于获得性免疫缺陷综合征(艾滋病)而不是终生 抗逆转录病毒疗法(ART)。最佳抗逆转录病毒疗法可以阻止病毒复制，从而防止疾病进展和 允许免疫重建。然而，由于病毒的潜伏形式持续存在，抗逆转录病毒治疗并不是治愈的。 这种潜伏的形式是治愈的主要障碍，也是国际上密集研究的主题。沿着 随着开发艾滋病毒疫苗的努力，针对艾滋病毒潜伏宿主是艾滋病研究的主要优先事项。 更好地了解艾滋病毒感染的基本生物学可能是治愈艾滋病毒的关键。 努力。这次会议将汇聚研究艾滋病毒病毒学基本方面的科学家以及 直接致力于治愈问题的调查人员。基于免疫的清除感染细胞的策略是一种 许多治疗策略的重要组成部分，为举行联合会议提供了一个合理的联系 艾滋病疫苗。这种配对将提供一个独特的机会，将基础和翻译结合在一起 免疫学家和病毒学家考虑治愈艾滋病毒感染的具有挑战性的目标。除关节外 会议聚焦于艾滋病毒抗体和T细胞反应研究的令人振奋的新发展 将有助于未来艾滋病毒生物学研究的新技术，会议还包括艾滋病毒的基本机制 整合和转录控制，逆转潜伏期和消除感染细胞的策略，以及试验 在动物模型和接受抗逆转录病毒治疗的患者中研究新的治疗策略。这次会议的目标是为 基础科学家和应用科学家共同致力于功能性治疗和根除艾滋病毒 努力不仅更好地了解艾滋病毒治疗战略，而且更好地了解新兴技术和 将导致最终从感染者身上根除艾滋病毒的方法。

ABSTRACT Support is requested for a Keystone Symposia conference entitled HIV Pathogenesis and Cure, organized by Drs. Robert F. Siliciano, Carine M. Van Lint and Romas Geleziunas. The conference will be held in Keystone, Colorado from March 22-26, 2020. Human Immunodeficiency Virus type 1 (HIV) is the cause of a global pandemic that has a very high mortality rate, with an estimated 35 million deaths to date. In addition, another 37 million people are currently living with HIV infection and will likely succumb from acquired immune deficiency syndrome (AIDS) without lifelong antiretroviral therapy (ART). Optimal ART can halt viral replication, thereby preventing disease progression and allowing immune reconstitution. However, ART is not curative due the persistence of a latent form of the virus. This latent form is the major barrier to cure and the subject of an intense international research effort. Along with efforts to develop an HIV vaccine, targeting the HIV latent reservoir is a major priority for AIDS research. Achieving a better understanding of the basic biology of HIV infection is likely to be essential to HIV cure efforts. This conference will bring together scientists studying basic aspects of HIV virology as well as investigators working directly on the cure problem. Immune-based strategies to eliminate infected cells are an important component of many cure strategies, providing a logical connection to hold the joint conference on HIV Vaccines. This pairing will provide a unique opportunity to bring together basic and translational immunologists and virologists to consider the challenging goal of curing HIV infection. In addition to joint sessions focusing on exciting new developments in the study of antibody and T cell responses to HIV and novel technologies that will aid future studies of HIV biology, sessions also include basic mechanisms of HIV integration and transcriptional control, strategies for reversing latency and eliminating infected cells, and trials of novel cure strategies in animal models and in patients on ART. The goal of this conference is to bring together an amalgamation of basic and applied scientists working on functional cures and eradication of HIV in an effort to not only better understand HIV treatment strategies but also the emerging technologies and approaches that will lead to the eventual eradication of HIV from infected individuals.