Innovative Vaccine Approaches

摘要 要求为题为创新疫苗办法的Keystone专题讨论会提供支助， 作者：Mariagrazia Pizza、Galit Alter和Gordon Dougan博士。会议将在加拿大的温哥华举行 2021年6月27日至7月1日。 疫苗有能力预防和潜在地根除广泛的传染病， 这是我们应对全球健康威胁的最有效的救生措施之一。近期 冠状病毒大流行使疫苗开发工作的重要性和紧迫性变得更加突出 专心点此外，疫苗学领域正在迅速发展，这要归功于我们对疫苗的理解的进步。 微生物学、免疫学和基因组学，以及抗原和抗原- 抗体复合物和变异的影响。多年来，这一领域也经历了一个澄清， 免疫和保护机制，以及相关因素的识别。然而，许多问题仍然存在。 需要解决未解决的和创新的方法来应对新的疫苗挑战， 耐药性、新出现的传染病、癌症和与我们人口老龄化有关的疾病。这 会议将讨论疫苗开发的最新进展和新方法，包括：（1） 新的抗原递送系统;（2）用于疫苗评估的体外和体内模型系统;（3）使用 人类挑战模型;（4）“系统生物学”在免疫相关性综合分析中的作用， 生物标志物识别和安全性;（5）机器学习方法，以定义抗体之间的相关性 疫苗库和保护;（6）为经济困难的人开发低成本疫苗的战略 人口数量。这些主题将为与会者提供新的想法和工具，以继续打造新的 疫苗能力的前沿。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innovative Vaccine Approaches, organized by Drs. Mariagrazia Pizza, Galit Alter and Gordon Dougan. The conference will be held in Vancouver, Canada from June 27- July 1, 2021. Vaccines have the power to prevent and potentially eradicate a wide range of infectious diseases, representing one of the most effective life-saving measures at our disposal against global health threats. The recent coronavirus pandemic has brought the importance and urgency of vaccine development efforts into sharp focus. Moreover, the vaccinology field is evolving very rapidly, thanks to advances in our understanding of microbiology, immunology and genomics, as well as advances in structural analysis of antigens and antigen- antibody complexes and impacts of variation. Over the years, this field has also experienced an elucidation of mechanisms of immunity and protection, and identification of correlates. However, many questions are still unsolved and innovative approaches are needed to address new vaccine challenges like antimicrobial resistance, emerging infectious diseases, cancer and diseases associated with our aging population. This conference will cover the latest advances and novel approaches towards vaccine development, including: (1) novel antigen delivery systems; (2) in vitro and in vivo model systems for vaccine appraisal (3) the use of human challenge models; (4) the role of ‘systems biology’ in the comprehensive analysis of immune correlates, biomarker identification and safety; (5) machine-learning approaches to define correlations between antibody repertoires and protection; and (6) strategies for developing low cost vaccines for economically challenged populations. Together these topics will provide attendees with the new ideas and tools to continue to forge new frontiers in vaccine capabilities.