Innovative Vaccine Approaches

创新疫苗方法

• 批准号: 10237543
• 负责人: Thale Cross Jarvis
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-23 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10237543
• 关键词: Address; Antibody Repertoire; Antibody-mediated protection; Antigen-Antibody Complex; Antigens; Antimicrobial Resistance; Biological Models; COVID-19 pandemic; Canada; Clinical Trials; Collaborations; Communicable Diseases; Communities; Coronavirus; Disease; Educational workshop; Emerging Communicable Diseases; Ensure; Epidemic; Event; Future; Genomics; Human; Immersion; Immune; Immunity; Immunology; In Vitro; Knowledge; Life; Machine Learning; Malignant Neoplasms; Measures; Methodology; Microbiology; Modeling; Outcome; Population; Privatization; Research; Research Personnel; Role; Safety; Savings; Scientist; Structure; System; Systems Biology; Techniques; Vaccines; Variant; aging population; biomarker identification; clinical practice; cost; experience; frontier; global health; in vivo Model; innovation; manufacturability; next generation; novel; novel strategies; novel vaccines; pandemic disease; posters; prevent; symposium; tool; vaccine development; vaccine discovery; vaccinology

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innovative Vaccine Approaches, organized by Drs. Mariagrazia Pizza, Galit Alter and Gordon Dougan. The conference will be held in Vancouver, Canada from June 27- July 1, 2021. Vaccines have the power to prevent and potentially eradicate a wide range of infectious diseases, representing one of the most effective life-saving measures at our disposal against global health threats. The recent coronavirus pandemic has brought the importance and urgency of vaccine development efforts into sharp focus. Moreover, the vaccinology field is evolving very rapidly, thanks to advances in our understanding of microbiology, immunology and genomics, as well as advances in structural analysis of antigens and antigen- antibody complexes and impacts of variation. Over the years, this field has also experienced an elucidation of mechanisms of immunity and protection, and identification of correlates. However, many questions are still unsolved and innovative approaches are needed to address new vaccine challenges like antimicrobial resistance, emerging infectious diseases, cancer and diseases associated with our aging population. This conference will cover the latest advances and novel approaches towards vaccine development, including: (1) novel antigen delivery systems; (2) in vitro and in vivo model systems for vaccine appraisal (3) the use of human challenge models; (4) the role of ‘systems biology’ in the comprehensive analysis of immune correlates, biomarker identification and safety; (5) machine-learning approaches to define correlations between antibody repertoires and protection; and (6) strategies for developing low cost vaccines for economically challenged populations. Together these topics will provide attendees with the new ideas and tools to continue to forge new frontiers in vaccine capabilities.

抽象的 请求支持Keystone研讨会会议，标题为“创新疫苗方法” 由Drs。 Mariagrazia Pizza，Galit Alter和Gordon Dougan。会议将在加拿大温哥华举行 从2021年6月27日至7月1日。 疫苗有能力预防和潜在地放射各种传染病，代表 我们应对全球健康威胁的最有效挽救生命的措施之一。最近 冠状病毒大流行使疫苗开发工作的重要性和迫切性变成了敏锐的 重点。此外，疫苗学领域的发展迅速，感谢您对我们的理解的进步 微生物学，免疫学和基因组学，以及抗原和抗原的结构分析的进步 抗体复合物和变异的影响。多年来，该领域还经历了 免疫学和保护的机制，以及相关性的识别。但是，许多问题仍然存在 需要采用未解决和创新的方法来应对抗菌素等新的疫苗挑战 抗药性，新兴的传染病，癌症和与我们老龄化的疾病。这 会议将涵盖疫苗开发的最新进展和新颖方法，包括：（1） 新型抗原递送系统； （2）用于疫苗评估的体外和体内模型系统（3）使用 人类挑战模型； （4）“系统生物学”在免疫相关的综合分析中的作用， 生物标志物识别和安全； （5）定义抗体之间相关性的机器学习方法 曲目和保护； （6）为经济挑战开发低成本疫苗的策略 人群。这些主题将共同为与会者提供新的想法和工具，以继续锻造新的想法 疫苗能力的前沿。