A Wireless CMOS Device for Rapid Point-of-Care Diagnosis of Bacterial Infections and Antibiotic Susceptibility Profiling

用于细菌感染快速护理诊断和抗生素敏感性分析的无线 CMOS 设备

• 批准号: 462274-2014
• 负责人: Gulak, Glenn
• 金额: $ 17.44万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=576858
• 关键词: Wireless; CMOS; Device; Rapid; Point

The Canadian Foundation for Infectious Diseases estimates that 25% of all physician visits are related to infectious diseases and result in a total cost of >$12billion annually for treatment and lost productivity. We have developed a disposable microchip that is able to identify and type live bacteria in less than ten minutes with no bacterial culturing steps required. This technology combines the specificity of viruses (phages) that infect and kill bacteria with the sensitivity of integrated electronic circuits to create a low-cost, portable detection system. The system can also be used to allow rapid antibiotic susceptibility profiling that would provide positive antibiotic stewardship.

加拿大传染病基金会估计，所有医生就诊中有25%与传染病有关 并且导致每年用于处理和损失生产力的总成本> 120亿美元。我们开发了一种一次性的 这种微芯片能够在不到10分钟的时间内识别和分型活细菌，无需细菌培养步骤。 该技术将感染和杀死细菌的病毒的特异性与集成的灵敏度相结合。 电子电路来创建低成本的便携式检测系统。该系统还可用于快速抗生素 敏感性分析，这将提供积极的抗生素管理。