Acquisition of a 500 MHz NMR Spectrometer

核磁共振（NMR）光谱是化学家用来研究分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱学对于正在进行前沿研究的化学家来说是必不可少的。这项来自化学共享仪器计划的奖励将帮助哈佛大学化学系获得一台高场核磁共振光谱仪。此次收购将加强的化学研究领域包括：1)以酶为催化剂的低聚物和多糖有机合成3)新的有机和有机金属反应的发现和发展及相关的合成方法4)小分子酶模拟物的设计5)c -糖苷和糖苷的构象分析6)核磁共振和有机合成方法对天然产物结构的阐明7)复杂合成中间体的结构解析。

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists who are carrying out frontier research. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemistry at Harvard University to acquire a high-field NMR spectrometer. Among the areas of chemical research that will be enhanced by the acquisition are the following: 1) Organic synthesis of oligo- and polysaccharides using enzymes as catalysts 2) Synthetic, bio-organic, and medicinal chemistry 3) Discovery and development of new organic and organometallic reactions and associated synthesis methodology 4) The design of small molecule enzyme mimics 5) Conformational analysis of C-glycosides and glycosides 6) Natural product structure elucidation by the methods of NMR and organic synthesis 7) Structure elucidation of complex synthetic intermediates.