MRI: Acquisition of an LC/MS system for Middlebury College

米德尔伯里学院化学和生物化学系将从主要研究仪器(MRI)计划获得这一奖项，并将获得一台液体色谱仪离子陷阱串联质谱仪(LC/MS)。该设备将加强多个领域的研究，包括a)过渡金属-多烯络合物的自由基反应的研究；b)与具有高对映选择性的烯丙基钯络合物进行烯丙化反应的方法；c)与常用药物顺铂密切相关的抗癌化合物的作用机理；以及d)美拉德反应的研究。这一仪器将大大加强米德尔伯里学院的科学研究，该学院主要是一所本科院校。这些研究将在合成有机化学和药物化学领域产生坚实的影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Middlebury College will acquire a liquid chromatograph ion trap tandem mass spectrometer (LC/MS). This equipment will enhance research in a number of areas including a) studies on radical reactions of transition metal-polyene complexes; b) methods for carrying out allylation reactions with allyl palladium complexes with high enantioselectivity; c) studying the mechanism of action of anti-cancer compounds closely related to the commonly prescribed drug, cisplatin; and d) studies of the Maillard reaction.Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at Middlebury College, a primarily undergraduate institution. These studies will have a solid impact in the area of synthetic organic chemistry and medicinal chemistry.