Acquisition of a Cryoprobe for a NMR Spectrometer

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在化学研究仪器和设施：多用户计划（CRIF：MU）的支持下，德克萨斯A M大学主校区的化学系将获得用于500 MHz核磁共振（NMR）光谱仪的冷冻探针。此次收购所提供的更高灵敏度将推动各种研究项目，包括：1）分析来自水生生物的天然产物分子，仅获得少量; 2）通过定量NMR光谱学研究反应机理，即使是稀释样品也需要高信噪比，以达到必要的精度; 3）少量不稳定的有机金属化合物和催化过渡态的研究;和4）酶结合的中间体的调查和使用同位素富集的蛋白质样品的膜运输实验。核磁共振波谱是一种非常强大的分析技术，用于化学、生物化学和生物学研究中的材料分析。光谱使研究人员能够识别和表征其物质，包括反应中的瞬态中间体。它们提供了分子和材料中原子排列和连接的信息，即，通过探测原子核自旋性质引起的能级之间的跃迁来研究它们的结构。冷冻探针将对壁内和壁外的教育产生重大影响。在得克萨斯州A M，研究生和本科研究生将受益于从最先进的仪器获得数据的能力。此外，为加强区域影响，该文书将具备网络功能。校外用户将能够发送他们的样品，并将有选择的光谱获得的工作人员，或执行实验本身通过远程控制的光谱仪。得克萨斯大学泛美分校、得克萨斯农工大学科珀斯克里斯蒂分校、得克萨斯农工大学金斯维尔分校、塔尔顿州立大学和得克萨斯大学二叠纪盆地分校的教师将可以使用光谱仪。许多这些机构有很高的西班牙裔入学率，使这一收购提供给大量代表性不足的学生。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Chemistry Department at Texas A&M University Main Campus will acquire a cryoprobe for a 500 MHz nuclear magnetic resonance (NMR) spectrometer. The increased sensitivity provided by this acquisition will advance a variety of research projects, including: 1) Analysis of natural product molecules from aquatic organisms, obtained only in small amounts; 2) Investigations of reaction mechanisms by quantitative NMR spectroscopy, requiring a high signal-to-noise ratio even of dilute samples, to achieve the necessary precision; 3) Studies of small amounts of unstable organometallic compounds and catalytic transition states; and 4) Investigations of enzyme-bound intermediates and membrane transport experiments employing isotopically enriched protein samples. NMR spectroscopy is a very powerful analytical technique for the analysis of materials in chemistry, biochemistry and biology research. The spectra enable researchers to identify and characterize their substances including transient intermediates from reactions. They provide information on the arrangement and connectivity of atoms in molecules and materials, i.e., their structures by detecting transitions between energy levels arising from the nuclear spin properties of atoms. The cryoprobe will have a significant impact on education both intra- and extramurally. At Texas A&M, graduate and undergraduate research students will benefit from the ability to obtain data from state-of-the-art instrumentation. In addition, to enhance regional impact, the instrument will be cyber enabled. Off campus users will be able to send their samples, and will have the choice of having spectra obtained by staff, or of performing the experiments themselves by remote control of the spectrometer. Faculty at the University of Texas-Pan American, Texas A&M University Corpus Christi, Texas A&M University Kingsville, Tarleton State University, and the University of Texas of the Permian Basin will have access to the spectrometer. Many of these institutions have high Hispanic enrollments making this acquisition available to significant numbers of underrepresented students.