Basic and overall studies to solve the factors preventing the implantable total artificial heart

1.流动变换脉动全人工心脏(FTPTAH)的研制研究了离心式血泵的新结构，以降低泵内的血液混合率，并成功地将血液混合率降低到20%。设计了波动泵和4个水母瓣相结合的新型FTPTAH机构，减小了体积，改善了血液相容性，降低了能量消耗。2.研制了由2个波动泵和2个无刷直流电机组成的波动泵全人工心脏，这是世界上最小的机械全人工心脏。对泵的制作方法和控制UPTAH的软件进行了基础研究。将UPTAH植入一只体重41 kg的山羊的胸腔内，成功地存活了约11天。3.THA新的TAH控制方法的研究，即1/R控制法，即TAH山羊通过生物反馈机制改变她的外周总阻力来控制自己的机械心脏，并成功地在一只山羊身上存活了532天，没有任何病理生理状态，这是世界上TAH存活时间最长的TAH控制方法。4.对TAH聚合物表面钙化机理的新假说通过对一只超过300天的水母阀门钙化表面的分析，发现了一个新的现象，即钙化集中在承受反复拉力的点。提出了一种新的假说，可以解释钙化产生的原因。5.新型传感器的研制开发了一种用于测量血液中血儿茶酚胺水平的传感器和一种用于长期观察微循环的植入式探头。

The following results have been obitained through 3 years research.1.Development of flow transformed pulsatile total artificial heart (FTPTAH)New structures of centrifugal blood pump were studies to reduce the blood mixture rate inside the pump and succeeded to reduce the blood mixture rate to 20 %. New mechanism of FTPTAH having the combination of undulation pump and 4 jellyfish valves was designed to reduce the size, to improve blood compatibility and to reduce the energy consumption.2.Development of undulationpump total artificial heart (UPTAH)UPTAH has been constructed with 2 undulation pumos and 2 brushless DC motor, that is the smallest mechanical TAH in the world. The basic studies concerning the fabrication method of the pump and the software to control UPTAH have been performed. As the results of these studies, UPTAH was implanted into the chest cavities of a goat weighing 41Kg and succeeded to survive her for about 11 days.3.The study of physiological control of TAHA new TAH control method, 1/R control method, in which the goat with TAH controls her own mechanical heart by changing her total peripheral resistance through biofeedback mechanism, was studied using pneumatically driven TAH and succeeded to survive a goat for 532 days without any pathophysiological state, which was the longest survivor under TAH in the world. The method is being studied to apply to UPTAH.4.New hypothesis concerning the mechanism of calcification on TAH polymer surfaceA new phenomena was found by analysing the calcified surface of a jellyfish valve drived over 300 days, that the calcification was concentrated at the point where received a repeated stretching force. A new hypothesis that could explain why the calcification was generated such a point, was proposed.5.Development of new senaorsA sensor to measure the blood chatecholamine level and a implantable probe to observe the microcirculation chronically, were developed.