Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH)

摘要 请求支持Keystone研讨会，题为非酒精性器官间相声 脂肪肝炎(NASH)，由Greg Steinberg、Camilla Charlotte Schéele和Saswata Talukdar博士组织。 大会将于2022年2月6日至9日在科罗拉多州的Keystone举行。 肥胖和2型糖尿病的流行正在推动非酒精性脂肪性肝炎的发展 (NASH)，这是迅速加速的肝硬变和肝细胞癌(肝癌)的速度。纳什是 以不同细胞类型和器官系统之间复杂的串扰为特征，导致脂肪变性， 炎症和纤维化。这种细胞内通信涉及多个细胞类型 微环境(例如，星状细胞、巨噬细胞、T细胞和肝细胞)，但也包括相互作用 具有多种器官系统(例如，肠道微生物组、棕色/米色/白色脂肪组织和肌肉)。与 许多新技术的发展(例如蛋白质组学、单细胞RNAseq和有机化合物)，我们的 对这些错综复杂的信号通路的了解正在迅速扩大。这次会议将有科学家参加 跨不同学科，为分享迅速出现的方法学进步提供一个论坛 为了了解细胞和器官系统交流的机制，以便发展 NASH治疗的新范式和治疗策略。鉴于脂肪组织的重要性 作为一个关键的储藏库，一个内分泌器官，一个能量消耗的调节器，这次会议将是 与Keystone研讨会联合举办脂肪组织和代谢健康会议，以扩大 跨学科互动的机会。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH), organized by Drs. Greg Steinberg, Camilla Charlotte Schéele and Saswata Talukdar. The conference will be held in Keystone, Colorado from February 6-9, 2022. The epidemics of obesity and type 2 diabetes are driving the development of non-alcoholic steatohepatitis (NASH) which is rapidly accelerating rates of liver cirrhosis and hepatocellar carcinoma (HCC). NASH is characterized by complex crosstalk between different cell types and organ systems that leads to steatosis, inflammation and fibrosis. This intracellular communication involves multiple cells types within the microenvironment (e.g., stellate cells, macrophages, T cells and hepatocytes) but also includes interactions with multiple organ systems (e.g., gut microbiome, brown/beige/white adipose tissue and muscle). With the development of many new technological advances (e.g., proteomics, single cell RNAseq, and organoids), our understanding of these intricate signaling pathways is rapidly expanding. The conference will bring scientists across different disciplines together to provide a forum for sharing rapidly emerging methodological advances in order to understand the mechanisms by which cells and organ systems communicate, in order to develop new paradigms and therapeutic strategies for the treatment of NASH. Given the importance of adipose tissue as a critical storage depot, an endocrine organ, and a regulator of energy expenditure, this conference will be held jointly with the Keystone Symposia meeting Adipose Tissue and Metabolic Health in order to expand opportunities for interdisciplinary interactions.