Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies

摘要 要求为题为“组织纤维化和修复：机制”的Keystone专题讨论会提供支助， 人类疾病和治疗，由Shelia Violette、Neil亨德森、Benjamin Humphreys和 梅兰妮·科尼肖夫会议将于2022年6月12日至16日在科罗拉多州基斯通举行。 纤维化是许多形式的器官衰竭的最终共同途径，也是发病率和死亡率的主要原因 国际吧传统上，纤维化的特征在于异常的成纤维细胞活化和不充分的组织修复。 虽然在理解驱动组织损伤的分子机制方面取得了进展， 尽管存在肝纤维化，但仍然需要鉴定与人类疾病相关并且可以被治疗的靶点/途径。 促进修复和再生，以及开发翻译策略，以促进临床 开发新的治疗方法。因此，本次会议旨在突出最近的进展， 对驱动组织损伤和纤维化的细胞和分子机制的理解， 以促进组织修复和再生。该计划将探索之间的接口 老化、衰老、组织损伤和纤维化。与会者还将了解单细胞基因组学如何 知情的细胞异质性，驱动组织损伤和纤维化的机制，以及可能导致组织损伤和纤维化的细胞/途径。 重新编程以促进修复和再生。其他主题包括翻译 支持对纤维化疾病的理解并促进药物开发的进展，例如模型 疾病易感性的预后标志物;疾病活动性的生物标志物;以及 侵入性技术，以诊断，诊断和监测治疗干预。该计划还将 强调开发新型纤维化疗法的最新进展。这一著名的会议将 为早期和成熟的国际研究人员提供互动论坛，阐明新的发现 促进富有成效的合作。此外，它将与另一个Keystone研讨会会议联合举行 关于炎症的解决方案。这些组织之间建立网络和科学合作的机会 协同领域将出现在共享会议和用餐的与会者在这两个会议。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies, organized by Drs. Shelia Violette, Neil Henderson, Benjamin Humphreys and Melanie Koenigshoff. The conference will be held in Keystone, Colorado from June 12-16, 2022. Fibrosis is a final common pathway in many forms of organ failure and a major cause of morbidity and mortality worldwide. Classically, fibrosis is characterized by aberrant fibroblast activation and inadequate tissue repair. While advances have been made in the understanding of molecular mechanisms driving tissue injury and fibrosis, there remains a need to identify targets/pathways that are relevant to human disease and can be leveraged to promote repair and regeneration, as well as to develop translational strategies to facilitate clinical development of novel therapies. Therefore, this conference is designed to highlight the recent advances in the understanding of cellular and molecular mechanisms driving tissue injury and fibrosis and their potential to be leveraged to promote tissue repair and regeneration. The program will explore the interface between aging, senescence, tissue injury and fibrosis. Participants will also learn how single-cell genomics has informed cellular heterogeneity, mechanisms driving tissue injury and fibrosis, and cells/pathways that can be reprogrammed to promote repair and regeneration. Other topics that will be covered include translational advances that support the understanding of fibrotic disease and facilitating drug development, such as models of human disease; prognostic markers of disease susceptibility; biomarkers of disease activity; and non- invasive technologies to diagnose, prognosticate, and monitor therapeutic intervention. The program will also emphasize recent advances toward developing novel fibrosis therapies. This renowned conference will provide an interactive forum for early and established international investigators, illuminate novel discoveries and facilitate fruitful collaboration. Moreover, it will be held jointly with another Keystone Symposia conference on Resolution of Inflammation. The opportunity for networking and scientific collaboration between these synergistic fields will occur during shared sessions and meals for attendees at both conferences.