Neuronal Control of Appetite

摘要 请求为题为食欲神经元控制的Keystone研讨会会议提供支助，由 理查德·西姆利博士、J·尼古拉斯·贝利博士和斯蒂芬妮·富尔顿博士。会议将在艾伯塔省的班夫举行 2022年3月20日至23日。 大脑如何协调多个生理和环境信号来调节体重仍然是一个 重要的和积极研究的生物学问题。此外，这个问题的答案是直接的 与肥胖管理的临床相关性；这一领域的大多数研究都适当地集中在 神经内分泌调节食物摄入量和能量消耗。这次Keystone研讨会是 旨在展示该领域最尖端的发现，这将进一步扩大我们的理解 在动机行为的背景下进行能量平衡调节。在一个动态的世界里，决定 食用食物是在权衡了相互竞争的需求后制作的，这些需求也必须得到解决，以确保生存，因为 个人寻求、消耗和储存能量。此外，神经系统也会奖励不合适的食物 入口处。本次会议将聚焦于人类在回路和系统层面上所取得的进展。 和动物模型，以了解食物的摄入如何以及何时优先，大脑如何整合相关的 感官信息，平衡相互竞争的需求，协调适应行为和相关 有效管理能量平衡的生理反应。本次大会还将探讨发展 完成这些整合过程的神经系统。其他课程将研究如何 环境和内感信号，以及神经炎症，可以改变组织和 这些神经系统的功能。我们将回顾各种不同的实验方法， 支持和挑战当前的能源平衡调控理念，并承诺提供丰富的框架 以供讨论和协作。最后，这次会议将与Keystone研讨会会议配对， 肠脑轴。会议将共享会议，并为双方的参与者提供最佳场所 召开会议，在这些领域进行互动和发展新的合作。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuronal Control of Appetite, organized by Drs. Richard Simerly, J. Nicholas Betley and Stephanie Fulton. The conference will be held in Banff, Alberta from March 20-23, 2022. How the brain coordinates multiple physiological and environmental signals to regulate body weight remains an important and actively investigated biological question. Moreover, the answer to this question has direct clinical relevance to the management of obesity; most of research in this area has focused, appropriately, on neuroendocrine regulation of food intake and energy expenditure. This Keystone Symposia conference was designed to the present the most cutting-edge findings in the field, which will further expand our understanding of energy balance regulation within the context of motivated behavior. In a dynamic world, the decision to consume food is made after weighing competing needs that also must be addressed to ensure survival as individuals seek, consume and store energy. Additionally, neural systems also reward inappropriate food intake. This conference will focus on the progress being done at both the circuit and systems level, in humans and animal models, to understand how and when food intake is prioritized, how the brain integrates relevant sensory information, balances competing needs, and coordinates adaptive behavior and associated physiological responses to effectively manage energy balance. This conference will also explore development of the neural systems that accomplish these integrative processes. Other sessions will examine how environmental and interoceptive signals, as well as neuroinflammation, can change the organization and function of these neural systems. A diverse array of experimental approaches will be reviewed that both support and challenge current concepts of energy balance regulation and promise to provide a rich framework for discussion and collaboration. Finally, this meeting is being paired with the Keystone Symposia conference, Gut Brain Axis. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations across these fields.