Organoids as Tools for Fundamental Discovery and Translation

摘要 请求支持Keystone研讨会，题为有机化合物作为基础的工具 由Jason Spence博士、Melissa Little博士和Barbara Treutlein博士组织的发现和翻译。这个 会议将于2022年4月3日至6日在科罗拉多州的Keystone举行。 有机化合物是一种复杂的三维体外器官模型系统。有机化合物可以从 多能干细胞或主要供体组织，已被用来解决关于 发育、干细胞生物学和器官再生。人类器官类化合物突出了重要的 人类生物学中的未知，并激发了对人体器官细胞组成的新探索 在发育过程中，在成人中，在疾病期间。努力改善有机系统的复杂性，以及 为了使有机化合物系统更加健壮、可重复性和可控性，促使人们努力在 体外有机系统与体内有机系统的比较，以及通过 生物工程方法。这次研讨会的目标是突出最新和正在出现的进展， 实现有机类化合物作为工具推动生物学的几个领域向前发展，包括提高复杂性和 成熟、高含量药物筛选、疾病建模以及了解发展和进化。我们 预计与会者将从这次会议中学到新的科学知识、新方法和新方法 技术能力。此外，鉴于有机化合物在基本发现和研究中的应用 翻译研究跨越了广泛的学科，这次会议很可能会聚集一个 不同的受众培养新颖的跨学科互动。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Organoids as Tools for Fundamental Discovery and Translation organized by Drs. Jason Spence, Melissa Little and Barbara Treutlein. The conference will be held in Keystone, Colorado from April 3-6, 2022. Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have highlighted significant unknowns in human biology and have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease. Efforts to improve complexity in organoid systems, and to make organoid systems more robust, reproducible and controlled have prompted efforts to benchmark in vitro organoid systems against their in vivo counterparts, and efforts to control organoid systems through bioengineering approaches. The goals of this symposium are to highlight recent and emerging advances that implement organoids as tools to move several areas of biology forward, including improving complexity and maturation, high content drug screening, disease modeling, and understanding development and evolution. We anticipate that attendees will take away from this meeting new scientific knowledge, new methods and new technical capabilities. Moreover, given that the implementation of organoids in basic discovery and translational research spans a wide range of disciplines, it is likely that this meeting will bring together a diverse audience fostering novel cross-disciplinary interactions.