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EFFECT OF ETHANOL ON CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT

EFFECT OF ETHANOL ON CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT
乙醇对大鼠脑血流和能量代谢的影响
批准号：
3808643
负责人：
A C MCLAUGHLIN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3808643
关键词：
alcoholic beverage consumption bioenergetics blood flow measurement brain metabolism diagnosis design /evaluation ethanol glucose metabolism laboratory rat oxygen consumption

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中文摘要
翻译
我们开发了一种新的技术来测量大脑皮层血流量， 大鼠，并将其与动脉/静脉差异的测量相结合 氧和葡萄糖来计算脑耗氧量， 脑葡萄糖消耗这项新技术的主要优点是 它可以用在未麻醉的自由移动的动物身上。大部分 先前关于酒精对脑血流影响的研究， 代谢率已经在限制或麻醉的动物上进行， 很难将压力和麻醉的影响与 酒精的影响。
英文摘要
We developed a new technique for measuring cortical cerebral blood flow in the rat, and combined it with measurements of arterial/venous differences for oxygen and glucose to calculate cerebral oxygen consumption and cerebral glucose consumption. The major advantage of this new technique is that it can be used in the unanesthetized, freely-moving, animal. Most of the previous studies on the effect of alcohol on cerebral blood flow and metabolic rate have been performed on restrained or anesthetized animals, where it is difficult to separate the effects of stress and anesthesia from the effects of alcohol.
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