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Cortactin: integrating cadherin signalling for junctional integrity

Cortactin: integrating cadherin signalling for junctional integrity
Cortactin:整合钙粘蛋白信号以实现连接完整性
批准号:
nhmrc : 1010489
负责人:
Prof Alpha Yap
金额:
$39.6万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

项目成果

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中文摘要
翻译
细胞间的粘连使人体保持在一起,并影响我们健康的许多方面,包括正常的组织和器官功能。重要的是,正常细胞-细胞粘附的丧失会导致许多疾病,包括癌症和炎症。一个关键的粘附分子,e -钙粘蛋白,是许多上皮组织所必需的,它的功能在疾病中受到干扰。本研究项目解决了e -钙粘蛋白如何向细胞发出信号来控制细胞间的相互作用。
英文摘要
Adhesion between cells holds the human body together and affects many aspects of our health, including normal tissue and organ function. Importantly, loss of normal cell-cell adhesion contributes to many diseases, including cancer and inflammation. One key adhesion molecule, E-cadherin, is necessary for many epithelial tissues and its function is perturbed in disease. This research project addresses how E-cadherin signals into cells to control cell-to-cell interactions.
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Forces in Nature: Tissue mechanics and cell sociology
  • 批准号:
    FL230100100
  • 项目类别:
    Australian Laureate Fellowships
  • 资助金额:
    $226.26万
  • 财政年份:
    2024
  • 负责人:
    Prof Alpha Yap
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Keeping forces local for epithelial homeostasis
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    2022
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RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
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    DP190102871
  • 项目类别:
    Discovery Projects
  • 资助金额:
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  • 财政年份:
    2019
  • 负责人:
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  • 依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
  • 批准号:
    nhmrc : 1140090
  • 项目类别:
    Project Grants
  • 资助金额:
    $73.78万
  • 财政年份:
    2018
  • 负责人:
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  • 依托单位:
海外基金