ANTI-HIV ACTIVITY OF ANTINEOPLASTONS

抗肿瘤激动素是一种从 尿液，并以其在各种癌症中的抗肿瘤作用而闻名。 这些药物目前正在用于感染艾滋病毒的患者。 治疗他们的淋巴瘤的个人。在…的过程中 治疗后发现HIV抗原水平下降。它 因此，有兴趣评估这些药物的抗艾滋病毒效果。 探员们。三种不同的抗肿瘤药，苯基钠 乙酰谷氨酸盐(PG)、乙酸苯钠(PN)和PG的混合物 和PN按1：4的比例在目标H9和H9中测试抗HIV U937细胞。使用的浓度分别为0.5%、0.1%、0.05%和0.025 初步结果表明，Pn和PG分别为0.05和0.1ug/ml 以最小的毒性抑制艾滋病毒复制50%以上。我们 目前正在评估这些药物的其他浓度 对艾滋病毒复制的影响。

Antineoplastons are peptides and amino acid derivatives isolated from urine and known for their antineoplastic effects in various cancers. These agents are currently being administered to HIV infected individuals for treatment of their lymphomas. In the course of treatment it was noticed that the HIV antigen levels decreased. It was therefore of interest to assess the anti-HIV effects of these agents. Three different antineoplastons, sodium phenyl acetylglutaminate (PG) sodium phenyl acetate (PN) and a mixture of PG and PN in the ratio of 1:4 were tested against HIV in target H9 and U937 cells. The concentrations used were 0.5, 0.1, 0.05, and 0.025 ug/ml. Preliminary results suggest that PN and PG at 0.05 and 0.1 ug/ml inhibit HIV replication by greater than 50% with minimal toxicity. We are at present evaluating other concentrations of these drugs for their effect on HIV replication.