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MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI

MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI
曼索尼血吸虫基因组和表面的分子研究
批准号：
3803120
负责人：
A SHER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3803120
关键词：
Bacillus Calmette Guerin vaccine Mycobacterium bovis Schistosoma mansoni T lymphocyte anthelmintics gene expression genetic markers helminthic antigen microorganism immunology molecular cloning molecular genetics parasitic disease chemotherapy schistosomiasis vaccines

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中文摘要
翻译
这个项目的目的是表征相关的血吸虫分子。 对免疫和发病机制的研究，分析其分子基础 可作为靶标的重要生理寄生虫过程 用于干预，并开发和测试重组疫苗。进展 在以下方面取得了成果： A.卡介苗-副肌球蛋白重组体的检测。被激发的免疫反应 通过将副肌球蛋白克隆到卡介苗中产生的疫苗重组 特色化的。 B.表达结合蛋白表位的重组克隆的鉴定 疫苗T细胞。对表达文库中的克隆进行筛选 从接种的小鼠中提取T细胞，以确定潜在的新免疫原。
英文摘要
The aim of this project is to characterize schistosome molecules relevant to immunity and pathogenesis, to analyze the molecular basis of physiologically important parasite processes which could serve as targets for intervention, and to develop and test recombinant vaccines. Progress was achieved in the following areas: A. Testing of BCG-paramyosin recombinants. The immune response stimulated by a vaccine recombinant produced by cloning paramyosin into BCG was characterized. B. Identification of recombinant clones expressing epitopes reactive with vaccine T cells. Clones from an expression library were screened against T cells from vaccinated mice in order to identify potential new immunogens.
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会议论文
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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