ACQUIRED IMMUNE DEFICIENCY SYNDROME

艾滋病患者有发展严重眼部问题的风险， 其中一些可能导致失明。如果不治疗，CMV视网膜炎是一种 艾滋病患者失明的主要原因。我们研究了 新的抗病毒药物膦甲酸，并确定其抑制 病毒的发展。我们也开始调查 用激光光凝进行连续治疗， 疾病。 在我们的研究过程中，我们还发现了 艾滋病患者的已知传染源，即HZV视网膜炎。在 与国家癌症研究所儿科分支合作，我们 一直在跟踪大约125名有症状的艾滋病毒感染儿童， 疾病的自然史，并确定 这些儿童中存在严重的眼部疾病。

Patients with AIDS are at risk of developing significant ocular problems, some of which can lead to blindness. Left untreated, CMV retinitis is a major cause of blindness in AIDS patients. We have looked at the effect of the new antiviral drug foscarnet and determined its ability to inhibit progression of the virus. We have also started investigating the usefulness of adjunctive therapy with laser photocoagulation in preventing progression of the disease. In the course of our studies, we have also identified new manifestations of known infectious agents in patients with AIDS, namely, HZV retinitis. In conjunction with the Pediatric Branch of the National Cancer Institute, we have been following about 125 children with symptomatic HIV to determine the natural history of the disease and to determine the probability of significant ocular disease in these children.