课题基金 / 基金详情

CHEMISTRY AND METABOLISM OF QINGHAOSU, A CHINESE ANTIMALARIAL DRUG

CHEMISTRY AND METABOLISM OF QINGHAOSU, A CHINESE ANTIMALARIAL DRUG
国产抗疟药青蒿素的化学和代谢
批准号：
3918275
负责人：
A BROSSI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3918275
关键词：
X ray crystallography antimalarial agents dimer drug design /synthesis /production drug screening /evaluation malaria pyrans sesquiterpenes

项目摘要

项目成果

A BROSSI的其他基金

相似基金

相关文献

中文摘要
翻译
由脱氧蒿乙醚和 通过在乙醇中用酸处理确定其α-异构体。 可以表明，该反应通过中间体进行， 乙烯基醚 用甲苯处理脱氧二氢青蒿素 在苯中的磺酸得到二聚体， 其结构通过X射线分析。 这些化合物是在 与世卫组织抗疟药蒿乙醚方案的联系 由中药青蒿素制成。
英文摘要
Structure of 11-epi-deoxyarteether formed from deoxyarteether and its alfa-isomer by treatment with acid in ethanol was established. It could be shown that this reaction proceeds via an intermediate vinylic ether. Treatment of deoxydihydroquinghaosu with toluene sulfonic acid in benzene afforded a dimer which was elucidated in its structure by an X-ray analysis. These compounds were made in connection with the WHO-program on arteether, an antimalarial prepared from the Chinese drug quinghaosu (artemisinin).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
STUDIES REGARDING THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
PHYSOSTIGMINE AND ANALOGS
NORTROPANE ALKALOIDS
海外基金