IMMUNOPATHOLOGY IN THE EYES WITH EXPERIMENTAL AUTOIMMUNE UVEITIS

免疫活性细胞的鉴别和拓扑定位， 啮齿类动物眼常驻细胞表面标志物的改变 实验性自身免疫性葡萄膜视网膜炎 或过继转移的细胞通过免疫组织化学研究进行分析。 发现炎症部位的淋巴细胞群 在疾病过程中有明显的变化。 在早期阶段， 辅助/诱导T细胞是眼睛中的主要细胞。 的相对 晚期T细胞抑制/细胞毒性细胞增加， 观察 主要组织相容性复合体II类的表达 眼部常驻细胞（例如RPE、视网膜内皮细胞）上的抗原， 角膜基质细胞、成纤维细胞和睫状体上皮 EAU的不同模型。 这种抗原表达可能在 在EAU的发病中有一定作用。 两者均浸润（细胞 亚群）和眼表II类抗原的表达 常驻细胞，可以通过不同的免疫抑制剂调节， 剂. 过继转移S抗原特异性抗体诱发EAU的动力学 T淋巴细胞系已经表明，这种细胞系可以识别 体内感光细胞S-Ag。 眼部免疫病理学 小鼠EAU可表现为慢性肉芽肿性肉芽肿， 炎症 视网膜下新生血管的发展可能 发生. 主要组织相容性复合体II类的表达 抗原仅位于眼驻留细胞上， 炎性细胞。

Identity and topographic localization of immunocompetent cells and alteration of surface markers on ocular resident cells in rodents with experimental autoimmune uveoretinitis by active immunization or adoptive transfer were analyzed by immunohistochemical studies. The lymphocyte population at the inflammatory sites was found to change markedly during the course of disease. In the early stage, T-helper/inducers are the predominant cells in the eye. A relative increase of T-suppressor/cytotoxic cells in the late stage were observed. Expression of major histocompatibility complex class II antigens on ocular resident cells such as RPE, retinal endothelium, keratocytes, fibroblast and ciliary epithelium was observed in different models of EAU in rats. This antigen expression may play a certain role in the pathogenesis of EAU. Both infiltrating (cell subpopulation) and expression of class II antigens on ocular resident cells, can be modulated by different immunosuppressive agents. Dynamics of EAU induced by adoptive transfer of S-antigen-specific T-lymphocyte cell line has showed that this cell line can recognize the photoreceptor S-Ag in vivo. Immunopathology in the eyes with EAU in mice can be presented as a chronic granulomatous inflammation. Development of subretinal neovascularization may occur. Expression of major histocompatibility complex class II antigens is only located on ocular resident cells with the presence of inflammatory cells.