IMMUNOPATHOLOGY OF OCULAR ONCHOCERCIASIS

12例盘尾丝虫病患者和10例患者的眼球标本和血清 对照组进行了研究。轻至中度慢性炎性细胞 盘尾丝虫病的结膜有浸润。 病人。T淋巴细胞是主要的炎性细胞， T细胞抑制亚群在盘尾丝虫病中的显著升高 将患者与对照组进行比较。在盘尾丝虫病患者中， 结膜和虹膜中的非淋巴样细胞，如血管内皮细胞， 周细胞和成纤维细胞，显示II类分子表达增加 抗原。血清和房水中抗蜗牛抗体的检测 与对照组相比，患者的幽默感明显更高。 这些发现表明T细胞在眼睛免疫中很重要。 日本血吸虫对丝虫免疫应答及第II类抗原表达 非淋巴样细胞和体液因素都可能在 眼部盘尾丝虫病。

Ocular specimens and sera from 12 patients with onchocerciasis and 10 controls were studied. A mild to moderate chronic inflammatory cellular infiltration was present in the conjunctiva of the onchocerciasis patients. T-lymphocytes were the predominant inflammatory cells with the T-suppressor subset being significantly increased in the onchocerciasis patients when compared to controls. In the onchoceriasis patients, the nonlymphoid cells in the conjunctiva and iris, such as vascular endothelia, pericytes and fibroblasts, showed an increase in expression of class II antigens. The anti-onchocerca Volvulus antibodies in the sera and aqueous humor were significantly highter in the patients compared to the controls. These findings suggest that T-cells are important in the ocular immune response to onchocerca and that expression of class II antigens on nonlymphoid cells and the humoral factors may all play a critical role in ocular onchocerciasis.