NIEHS Statistical Consulting Service

统计咨询服务（SCS）于1996年正式成立，为NIEHS研究人员进行的实验室和人类/流行病学研究中获得的数据的设计，分析和解释提供统计和计算专业知识。SCS提供的统计专业知识包括有关数据分析的建议，以及更广泛的合作研究工作，这些工作导致在主题期刊上联合发表文章。这些咨询项目涉及各种科学工作，包括实验室和人体研究。来自生物统计分支的一些统计学家在不同程度上参与了SCS。本资源审查报告总结了生物统计学分支统计学家向NIEHS专家组提供的咨询/合作。 项目合作的例子包括： (i)出生前暴露于艾滋病毒/艾滋病药物AZT、3 TC和AZT+3 TC对小鼠心脏损伤，特别是线粒体DNA的影响。 (ii)研究卡瓦提取物，一种常见的膳食补充剂，对肝脏细胞增殖和胆固醇水平的影响。 (iii)二（2-氯乙氧基）甲烷染毒大鼠心脏组织基因表达变化的研究 (iv)一些抗氧化膳食补充剂对遗传上易患前列腺癌的小鼠的影响的研究。 (v)丙烯酰胺致癌机制的基因改造小鼠研究。 (vi)居民氡暴露对肺癌影响的研究。 (vii)子宫内膜发育不良对妊娠存活的影响。

The Statistical Consulting Service (SCS) was formally established in 1996 to provide statistical and computational expertise in the design, analysis, and interpretation of data obtained from laboratory and human/epidemiological studies conducted by the researchers at NIEHS. Statistical expertise provided by the SCS ranges from advice regarding data analysis to more extensive collaborative research efforts that result in joint publications in subject matter journals. These consulting projects involve a variety of scientific endeavors, including both laboratory and human studies. A number of statisticians from the Biostatistics Branch are involved in varying degrees with the SCS. This Resource Review report summarizes the consulting/collaborations provided by the Biostatistics Branch statisticians to the NIEHS DIR. Examples of project collaborations include; (i) Effect of pre-natal exposure to HIV/AIDS drugs AZT, 3TC, and AZT+3TC on cardiac damage, in particular the mitochondrial DNA, in mice. (ii) Study of the effects of kava extract, a common dietary supplement, on cell proliferation in liver and its effects on cholesterol levels. (iii) Study of changes in gene expression of heart tissue among rats exposed to bis (2-chloroethoxy) methane (iv) Study of the effects of some antioxidant dietary supplements in mice that were genetically predisposed to prostate cancer. (v) Study of the mechanism of acrylamide carcinogenicity using genetically modified mice. (vi) Study of the effects of residential exposure to radon on lung cancer. (vii) Effect of improper uterine lining development on survival of pregnancy.