MACROMOLECULAR CRYSTALLOGRAPHY REMOTE ACCESS COMMISSIONING

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。远程访问工具已经开发和实施，允许用户从远程位置控制SSRL的大分子晶体学束流线的实验。远程数据采集模式的初始调试由斯克里普斯研究所（TSRI）进行。在调试阶段，NIAID成员在圣地亚哥的TSRI进行了实地考察，观察了对BL11-1上约150个sars相关蛋白晶体的远程筛选。此外，澳大利亚的一个小组（Carr）使用BL9-2筛选晶体并收集了几个MAD数据集。在预定的光束时间内参与调试阶段的其他小组包括Kornberg（斯坦福大学）、Chan（俄亥俄州）、Bjorkman和Rees（加州理工学院）、Tsai（加州大学欧文分校）、Stevens（斯克里普斯研究所）和Hol（华盛顿大学）。总共有11次预定的运行是完全远程进行的。在调试阶段从用户那里获得的反馈改善了整个远程访问体验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Remote access tools have been developed and implemented that allow users to control experiments on SSRL¿¿s macromolecular crystallography beam lines from remote locations. Initial commissioning of the remote data collection mode was carried out with The Scripps Research Institute (TSRI). During the commissioning phase, NIAID members on a site visit at TSRI in San Diego observed the remote screening of ~150 SARS-related protein crystals on BL11-1. Also, a group in Australia (Carr) screened crystals and collected several MAD data sets using BL9-2. Other groups that participated in the commissioning phase during their scheduled beam time included Kornberg (Stanford University), Chan (Ohio State), Bjorkman and Rees (California Institute of Technology), Tsai (UC Irvine), Stevens (The Scripps Research Institute) and Hol (University of Washington). In all, 11 scheduled runs were carried out in a completely remote fashion. Feedback obtained from the users during the commissioning phase has lead to improvements in the overall remote access experience.