NEURAL CONTROL OF VISUAL VESTIBULAR BEHAVIOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 正常的姿势、平衡和稳定的视觉依赖于视觉和前庭系统之间的相互作用。本项目的研究旨在确定正常视觉-前庭注视行为的神经底物。我们已经发表的研究表明，FEF和MST中的神经元在凝视和获得控制中扮演着不同的角色。我们已经证明，FEF中的神经元携带着一种信号，其特征是眼睛加速凝视。 最后，我们在进行平滑追踪任务的过程中使用了目标扰动，结果表明大多数MST神经元在增益控制中的作用很小。在模型研究中，我们发现大脑皮层区域FEF和MST在凝视追踪中起互补作用。这包括分别对FEF和MST的追击启动和维持做出了巨大贡献。该项目的研究记录了包括皮质-桥脑-小脑通路在内的平行通路中的差异信号处理和凝视控制能力。这项工作促进了我们对在疾病或损伤中受损的感觉-运动神经回路的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normal posture, balance and stable vision are dependent on interactions between the visual and vestibular systems. Studies in this project are directed at defining the neural substrate for normal visual-vestibular gaze behavior. We have published studies that show neurons in FEF and MST play differential roles in gaze and gain control. We have shown that neurons in FEF carry a signal that features eye acceleration for gaze. Finally, we used target perturbatation during ongoing smooth pursuit task to show that most MST neurons play little role in gain control. In modeling studies we have shown that cortical areas FEF and MST play complimentary roles in gaze pursuit. This includes a strong contribution to pursuit initiation and maintenance in FEF and MST respectively. Studies in this project document differential signal processing and capability for gaze control in parallel pathways involving cortical-ponto-cerebellar pathways. This work advances our understanding of sensory-motor circuits that are compromised in disease or injury.