Structure-Function-Biological Organization - Almo, Chair

描述(由申请人提供)：本提案请求支持由Steven C.Almo、Anna Marie Parle和Wah Chiu组织的题为结构-功能-生物组织的Keystone研讨会，该会议将于2012年1月22-27日在科罗拉多州Keystone举行。细胞功能需要复杂的过程在一个显著的长度和时间范围内的空间和时间协调。结构生物学--包括X射线、EM和核磁共振方法--有助于我们从机理上理解催化、分子识别和调控，并为调节这些过程提供独特的见解，以支持治疗干预。随着这些结构方法的不断成熟，它们已经走出了专家的领域，现在是现代生物学发现不可或缺的一部分。结构生物学的未来前景取决于我们将原子分辨率知识与尖端显微镜和光谱学以及互补的遗传、生化和化学生物学方法得出的结果相结合的能力。本次研讨会将突出多学科、多尺度综合方法在理解和操纵基本生物过程方面的力量，包括细胞运动、染色体维持、基因调控和膜相关现象。与会者还将有机会通过同时举行的高通量结构生物学会议，扩大他们对可用于研究复杂细胞系统的结构生物学进展的欣赏--该会议将与本次会议举行一次主旨会议和两次全体会议。 与公共卫生相关：随着人类基因组序列的出现，人类发育、生理和疾病的整个蓝图现已可用；然而，对这一蓝图的解释和开发仍然是一个重大挑战。关于结构-功能-生物组织的Keystone研讨会会议将突出多学科、多尺度综合方法的力量，以了解和开发将高分辨率结构信息整合到细胞生物学背景下的计划，以了解复杂细胞过程背后的长期组织原则。同时举行的高通量结构生物学会议将大大增加跨学科互动的机会--该会议将与本次会议举行一次主旨会议和两次全体会议。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Structure-Function-Biological Organization, organized by Steven C. Almo, Anna Marie Pyle and Wah Chiu, which will be held in Keystone, Colorado from January 22 - 27, 2012. Cellular function requires the spatial and temporal coordination of complex processes over a remarkable range of length and time scales. Structural biology - including X-ray, EM and NMR approaches - has been instrumental in contributing to our mechanistic understanding of catalysis, molecular recognition and regulation, as well as in providing unique insights into modulating these processes to support therapeutic intervention. As these structural approaches have continued to mature, they have moved out of the realm of the specialist and are now an essential and indispensible part of modern biological discovery. The future promise of structural biology rests on our ability to integrate atomic resolution knowledge with results derived from cutting-edge microscopies and spectroscopies, as well as complementary genetic, biochemical and chemical biological methodologies. This symposium will highlight the power of multi- disciplinary, multi-scale integrative approaches for understanding and manipulating fundamental biological processes, including cell motility, chromosome maintence, gene regulation and membrane-associated phenomena. Participants will also have an opportunity to broaden their appreciation of advances in structural biology that can be used for studying complex cellular systems via the concurrent meeting on High-Throughput Structural Biology - which will share a keynote and two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: With the advent of the human genome sequence, the entire blueprint for human development, physiology and disease is now available; however, interpretation and exploitation of this blueprint remains a major challenge. The Keystone Symposia meeting on Structure-Function-Biological Organization will highlight the power of multi-disciplinary, multi-scale integrative approaches for understanding and developing programs that integrate high resolution structural information in the context cell biology to understand the long-range organizational principles that underlie complex cellular processes. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on High-Throughput Structural Biology - which will share a keynote and two plenary sessions with this meeting.