Positive-Strand RNA Viruses

摘要 要求为题为正链RNA病毒的Keystone专题讨论会提供支助， Drs.弗兰克·货车·库佩维尔德和安德里亚·加马尼克。会议将于6月起在爱尔兰的基拉尼举行 2019年9月13日。 关于正链RNA病毒的Keystone研讨会提供了一个国际论坛， 研究具有正链RNA基因组的人类、动物、昆虫、植物和细菌病毒。这群 包含许多临床相关和众所周知的病原体（例如，脊髓灰质炎病毒，丙型肝炎病毒， 登革热和西尼罗河病毒）。此外，动物体内正链RNA病毒的巨大多样性 而昆虫，结合它们在物种跳跃后的进化和适应潜力， 越来越多的新出现的病毒，包括人畜共患病以及 虫媒病毒传播的病原体，如MERS-CoV、基孔肯雅病毒和寨卡病毒。详细了解 “病毒圈”、“病毒组”、病毒进化以及病毒复制和传播的分子细节， 组织嗜性和宿主免疫系统对病毒的识别对于理解病毒传播是至关重要的， 病毒的发病机制以及开发新的治疗和预防措施。本次会议带来了 聚集了经验丰富的和初级专家，讨论分子生物学，细胞生物学， 载体生物学、免疫学、疫苗学和抗病毒药物开发应用于正链领域 RNA病毒。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Positive-Strand RNA Viruses, organized by Drs. Frank van Kuppeveld and Andrea Gamarnik. The conference will be held in Killarney, Ireland from June 9-13, 2019. The Keystone Symposia conference on positive-strand RNA viruses provides an international forum for research on human, animal, insect, plant and bacterial viruses with positive-strand RNA genomes. This group of viruses contains many clinically relevant and well-known pathogens (e.g., poliovirus, hepatitis C virus, Dengue and West Nile virus). Furthermore, the enormous diversity of positive-strand RNA viruses in animals and insects, combined with their evolutionary and adaptive potential following a species-jump, poses a threat to the human population as demonstrated by the growing list of emerging viruses, including zoonotic as well as arbovirus-transmitted pathogens such as MERS-CoV, Chikungunya and Zika virus. Detailed insight into the “virosphere”, the “virome”, viral evolution, as well as in the molecular details of viral replication and spreading, tissue tropism, and viral recognition by the host immune system is critical to understand virus transmission, viral pathogenesis as well as to develop novel therapeutic and preventive measures. This conference brings together experienced and junior experts to discuss the latest developments in molecular biology, cell biology, vector biology, immunology, vaccinology, and antiviral drug development applied to the field of positive-strand RNA viruses.