Charting a New Course for Heart Failure: From Discovery to Data

摘要 要求支持一个题为“为心力衰竭制定新路线： 从发现到数据，由Mansoor Husain博士，Benoit G。Bruneau和Marc Pfeffer。的 会议将于2020年3月1日至5日在科罗拉多的Keystone举行。 心力衰竭是一个全球性的健康问题，其患病率、发病率和难治性死亡率不断增加， 相对来说，在这方面的治疗进展很少这一独特的多学科会议 将汇集领先的临床医生和科学家，分享遗传，环境， 心力衰竭的医源性和病理生理学机制。该计划包括具体的会议和 研讨会侧重于心脏纤维化，免疫学，代谢，再生医学， 生物医学工程，以及与这种疾病相关的大型数据集的分析方法。虽然 计划是多样化的，每一个会议将解决潜在的治疗心力衰竭生物学的科学前沿 相关性，并将制定解决一个悬而未决的，重要的临床问题。这种创新的形式是 有目的地计划突出心力衰竭的转化机会，并提供一个论坛， 鼓励心血管研究人员和具有不同观点的受训者之间的对话，但谁 都有一个共同的目标，那就是对心力衰竭产生影响。本次会议将与“新的见解”配对 “运动生物学”这两个Keystone研讨会会议将分享一个联合会议， 运动生理学以及它如何影响心脏能量学和肥大，这将是感兴趣的， 出席会议的观众。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Charting a New Course for Heart Failure: From Discovery to Data, organized by Drs. Mansoor Husain, Benoit G. Bruneau and Marc Pfeffer. The conference will be held in Keystone, Colorado from March 1-5, 2020. Heart failure is global health problem of increasing prevalence, high morbidity, and refractory mortality, for which there have been relatively few impactful therapeutic advances. This unique multidisciplinary conference will bring together leading clinicians and scientists to share the latest insights on genetic, environmental, iatrogenic and pathophysiological mechanisms of heart failure. The program includes specific sessions and workshops focused on advances in cardiac fibrosis, immunology, metabolism, regenerative medicine, biomedical engineering, and analytical approaches to large datasets of relevance to this disease. Although the program is diverse, each session will address a scientific frontier in heart failure biology of potential therapeutic relevance and will be framed to address an unanswered, important clinical question. This innovative format is purposefully planned to highlight translational opportunities in heart failure and to provide a forum that encourages dialogue between cardiovascular researchers and trainees with distinct perspectives, but who share a common goal of making an impact in heart failure. This conference will be paired with “New Insights into the Biology of Exercise.” These two Keystone Symposia conferences will share a joint session examining exercise physiology and how it affects cardiac energetics and hypertrophy, which will be of interest to audiences attending either conference.