From First Breath: Lung Development, Infection, Repair and Aging

摘要 请求支持一次题为《从第一次呼吸：肺发展， 感染、修复和衰老，由Carla Kim、Benjamin Singer和Nan Tang博士组织。会议将于 将于2023年4月23日至26日在犹他州雪鸟举行。 肺部疾病是全世界发病率和死亡率的主要原因。从产前开始 在发育过程中，由于衰老，肺在整个生命过程中都会经历变化，也会对此做出反应 对感染和其他有害刺激的反应。在单个细胞群体如何 随着时间的推移，协调和应对这些健康和疾病状态的变化。因此，这次会议 旨在解决特定细胞群如何对肺的形成和再生做出贡献 在整个生命过程中，以及检查新陈代谢、表观遗传学、应激反应和细胞-细胞相互作用 作为控制肺部生物学的特征，以及控制机制如何在生命的各个阶段发生变化。这一计划将 也旨在了解新兴技术和模型将如何阐明肺病的基本机制 健康和疾病，最后，如何阐明宿主对感染的免疫反应如何决定 修复性和再生性过程。作为这次会议的结果，与会者将有更全面的 对推动肺生物学的动力机制的看法，因为它与健康和疾病以及 理解这些概念的最新方法。最后，这次会议将与另一位 Keystone研讨会会议，“肺部炎症：病毒感染的朋友还是敌人？”这对情侣将 允许参与者弥合先天和后天进行的经典抗病毒反应之间的差距 免疫细胞和其他肺细胞，如上皮和间质细胞的参与，并加深 了解这些细胞是如何相互作用的。最终，这次研讨会将通过以下方式影响肺部生物学领域 将跨学科的科学家小组聚集在一起，共同推动机制的发现 潜在的肺部健康和疾病。

ABSTRACT Support is requested for a Keystone Symposia conference entitled From First Breath: Lung Development, Infection, Repair and Aging, organized by Drs. Carla Kim, Benjamin Singer and Nan Tang. The conference will be held in Snowbird, Utah from April 23 - 26, 2023. Lung diseases represent leading causes of morbidity and mortality worldwide. Beginning with antenatal development, the lung undergoes changes throughout the life course because of aging, as well as in response to infection and other injurious stimuli. There exist knowledge gaps in how individual cell populations coordinate and respond to these changes in states of health and disease over time. Therefore, this conference was designed to address how specific cell populations contribute to the formation and regeneration of the lung over the life course, as well as to examine metabolism, epigenetics, stress responses, and cell-cell interactions as features that control lung biology and how control mechanisms change over stages of life. This program will also aim to understand how emerging technologies and models will elucidate fundamental mechanisms of lung health and disease, and finally, how to articulate how the host immune response to infection determines reparative and regenerative processes. As a result of this meeting, attendees will have a more comprehensive view of dynamic mechanisms that drive pulmonary biology as it relates to health and disease as well as the newest approaches with which to understand these concepts. Finally, this conference will be held with another Keystone Symposia Conference, “Inflammation in the Lung: Friend or Foe in Viral Infections?” This pairing will allow participants to bridge the gap between classical antiviral responses carried out by innate and adaptive immune cells, and the involvement of other lung cells such as epithelia and stroma cells, and to deepen the understanding on how these cells interact. Ultimately, this Symposium will impact the field of lung biology by bringing together interdisciplinary groups of scientists that will synergize to propel discovery of mechanisms underlying lung health and disease.