Inflammation in the Lung: Friend or Foe in Viral Infections?

摘要 请求支持一个题为“肺部炎症：肺内的朋友或敌人”的Keystone研讨会。 病毒感染？由Andreas Wack博士、Cecilia Johansson博士和Ivan Zanoni博士组织。会议将 将于2023年4月23日至26日在犹他州雪鸟举行。 最近和以前的流行病和流行病已经戏剧性地显示了呼吸道病毒的能力， 感染会影响公共卫生，使社会陷入停滞。炎症占据了中心舞台，因为它是一种 它是抗病毒反应的重要组成部分，也建立了随后的适应性免疫反应和修复。 不幸的是，炎症也可能增加组织损伤，损害或延迟组织 再生本次会议旨在让与会者更好地了解炎症如何增强 或阻碍组织修复和再生，以及如何识别平衡的免疫介质 免疫病理学和保护之间的联系，并了解潜在的机制。而且这个 该计划将包括会议，将讨论先天免疫细胞在驱动炎症的作用， 反应并启动适应性免疫。该计划还将研究免疫系统之间的串扰 肺中的非免疫细胞影响疾病的结果，最后，它将突出新的途径和新的 治疗病毒感染的靶点。汇集宿主对病毒感染反应的专家， 致力于肺发育、修复和再生的科学家将产生通常不会产生的协同作用， 在一次专门会议上实现。最后，本次会议将与另一个Keystone研讨会一起举行 会议，“从第一次呼吸：肺发育，感染，修复和老化。”这种配对将允许 与会者之间的桥梁差距进行的经典抗病毒反应的先天性和适应性免疫 细胞，以及其他肺细胞如上皮细胞和间质细胞的参与，并加深 了解这些细胞如何相互作用。这种跨学科的互动将有助于促进合作， 开发治疗肺部感染引起的疾病的新角度。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Inflammation in the Lung: Friend or Foe in Viral Infections?, organized by Drs. Andreas Wack, Cecilia Johansson and Ivan Zanoni. The conference will be held in Snowbird, Utah from April 23 - 26, 2023. Recent and preceding pandemics and epidemics have dramatically shown the capacity of respiratory virus infections to impact public health and bring society to a standstill. Inflammation takes center stage as it is an important part of the anti-viral response and also sets up subsequent adaptive immune responses and repair. Unfortunately, inflammation also potentially increases tissue damage and impairs or delays tissue regeneration. This conference was designed for attendees to understand better how inflammation enhances or impedes tissue repair and regeneration, as well as how to identify immune mediators that tip the balance between immunopathology and protection and to understand underlying mechanisms. Additionally, this program will include sessions that will discuss the role of innate immune cells in driving the inflammatory response and initiate adaptive immunity. The program will also investigate how the crosstalk between immune and nonimmune cells in the lung affects disease outcomes, and finally, it will highlight new avenues and novel targets for treatment of viral infections. Bringing together experts in the host response to viral infections with scientists working on lung development, repair and regeneration will generate synergies that are not normally achieved in single specialized meetings. Finally, this conference will be held with another Keystone Symposia Conference, “From First Breath: Lung Development, Infection, Repair and Aging.” This pairing will allow participants to bridge the gap between classical antiviral responses carried out by innate and adaptive immune cells, and the involvement of other lung cells such as epithelia and stroma cells, and to deepen the understanding on how these cells interact. This cross-disciplinary interaction will help foster collaborations and develop new angles of treatment of diseases caused by lung infections.