B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers

摘要 请求支持一个题为“传染病背景下的B细胞生物学”的基石研讨会。 疾病，自身免疫和B细胞癌症，由苏珊皮尔斯和法昆多巴蒂斯塔博士组织。的 会议将于2023年6月6日至10日在科罗拉多的Keystone举行。 有效的B细胞抗体应答对于人类健康和保护免受致命的传染性疾病是必不可少的。 疾病然而，B细胞抗体也是破坏性自身免疫性疾病的介质，并且，当 B细胞恶性肿瘤从正常控制机制中释放出来是常见的，并且许多仍然无法治疗。它 成熟B细胞区室是高度异质的， 单个B细胞的命运取决于几个因素，包括B细胞受体（BCR）的亲和力 以及BCR如何与B细胞的激活机制相连，沿着免疫的质量 由抗原特异性T细胞和应答病原体的先天免疫细胞两者定义的环境- 衍生信号。产生针对B细胞恶性肿瘤或系统性 自身免疫性，可能代表的结果的频谱所造成的变化和相互作用之间 这些内在因素和周围环境。如果是这样的话，我们理性地操纵B细胞对 开发针对传染病的疫苗，以及针对自身免疫性疾病和B细胞 对B细胞生物学基本原理的详细了解可能会大大加快癌症的发生。的 将这些知识转化为临床和基础研究将使该领域能够解决最紧迫的问题， 我们这个时代的公共卫生优先事项，从急性和慢性传染病到自身免疫和B 细胞恶性肿瘤最后，这次会议将与艾滋病毒/艾滋病问题基石专题讨论会会议联合举行。 疫苗、免疫预防和药物。这种配对是理想的讨论如何B细胞异常有助于 艾滋病毒感染，特别是在抗体为基础的疫苗开发的潜力。的与会者 这两个会议将有机会通过共享会议、用餐时间和晚上的海报进行联网 sessions.

ABSTRACT Support is requested for a Keystone Symposia conference entitled B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers, organized by Drs. Susan Pierce and Facundo Batista. The conference will be held in Keystone, Colorado from June 6 - 10, 2023. Effective B cell antibody responses are essential for human health and protection against deadly infectious diseases. However, B cell antibodies are also mediators of devastating autoimmune diseases, and, when released from normal control mechanisms, B cell malignancies are common; and many remain untreatable. It is also becoming evident that the mature B cell compartment is highly heterogeneous and that antigen-driven fates of individual B cells are dependent on several factors, including the affinity of the B cell receptor (BCR) and how the BCR is wired to the B cell’s activation machinery, along with the quality of the immune environment as defined by both antigen-specific T cells and innate immune cells responding to pathogen- derived signals. The generation of long-lived protective immunity versus B cell malignancies, or systemic autoimmunity, may represent the spectrum of outcomes resulting from variations in and interactions between these intrinsic factors and the surrounding context. If so, our ability to rationally manipulate B cell responses to develop vaccines against infectious diseases, as well as therapies for autoimmune diseases and B cell cancers, may be greatly accelerated by a detailed understanding of the fundamentals of B cell biology. The translation of this knowledge to clinical and basic research will allow the field to address the most pressing public health priorities of our times, ranging from acute and chronic infectious diseases to autoimmunity and B cell malignancies. Finally, this conference is being held jointly with the Keystone Symposia conference, HIV Vaccines, Immunoprophylaxis and Drugs. This pairing is ideal to discuss how B cell abnormalities contribute to HIV infection, especially in terms of the potential for antibody-based vaccine development. Participants from both conferences will have the opportunity to network through shared sessions, mealtimes, and evening poster sessions.