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Metabolic wiring in adipocytes - unique role in maintaining long-term health

Metabolic wiring in adipocytes - unique role in maintaining long-term health
脂肪细胞的代谢线路——在维持长期健康方面的独特作用
批准号:
nhmrc : GNT1086850
负责人:
Prof David James
金额:
$103.62万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 --

项目摘要

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中文摘要
翻译
脂肪细胞代谢是有线优化细胞的能力,使和储存脂质,同时编程的细胞,以履行其功能,在整个身体的新陈代谢。我们将:1)在最佳和胰岛素抵抗条件下绘制脂肪细胞代谢图; 2)探索作为控制点预测的他的代谢回路中的3个节点的作用; 3)使用新的基因工程小鼠模型来探索脂肪细胞代谢在全身胰岛素敏感性中的功能意义。
英文摘要
Fat cell metabolism is wired to optimize the cell’s ability to make and store lipid while programming the cell to fulfil its function in whole body metabolism. We will: 1) map fat cell metabolism under optimal and insulin resistant conditions; 2) explore the role of 3 nodes in his metabolic circuit predicted as control points; 3) use a novel genetically engineered mouse model to explore the functional significance of fat cell metabolism in whole body insulin sensitivity.
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