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Metabolic wiring in adipocytes - unique role in maintaining long-term health

Metabolic wiring in adipocytes - unique role in maintaining long-term health
脂肪细胞的代谢线路——在维持长期健康方面的独特作用
批准号:
nhmrc : 1086850
负责人:
Prof David James
金额:
$71.87万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31

项目摘要

项目成果

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中文摘要
翻译
脂肪细胞的代谢是优化细胞制造和储存脂质的能力,同时对细胞进行编程,以实现其在全身代谢中的功能。我们将:1)绘制最佳和胰岛素抵抗条件下的脂肪细胞代谢图;2)探讨其代谢回路中预测的3个节点作为控制点的作用;3)利用新型基因工程小鼠模型探讨脂肪细胞代谢在全身胰岛素敏感性中的功能意义。
英文摘要
Fat cell metabolism is wired to optimize the cell’s ability to make and store lipid while programming the cell to fulfil its function in whole body metabolism. We will: 1) map fat cell metabolism under optimal and insulin resistant conditions; 2) explore the role of 3 nodes in his metabolic circuit predicted as control points; 3) use a novel genetically engineered mouse model to explore the functional significance of fat cell metabolism in whole body insulin sensitivity.
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