Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

摘要 请求支助题为《影响代谢的性别和性别因素》的Keystone专题讨论会 动态平衡、糖尿病和肥胖，由弗兰克·莫维斯-贾维斯博士、黛博拉·克莱格博士和亚瑟·P。 阿诺德。会议将于2017年2月19日至22日在加利福尼亚州塔霍市举行。有一些基本的 代谢稳态的各个方面，在男性和女性中受到不同的调节，并影响到 糖尿病和肥胖症的发展和药物干预的反应。尽管如此，大多数临床前 由于研究计划的复杂性，研究人员避免研究雌性啮齿动物。其后果是 是数据的生成可能只与一半的人口相关。这是一个及时的时刻 研究疾病中的性别差异NIH领导层要求科学家将性行为视为一种生物学 在临床前研究中变化不定，以确保女性从医学研究中获得与男性相同的好处。这个 这次会议的目标是通过将跨学科团体联系起来，满足科学界的需求 通常不会有机会互动的科学家。该小组包括研究人员 性别差异、性激素的作用、性的系统生物学和性的遗传贡献 染色体到代谢动态平衡和疾病。制药行业的领导者将出席 他们对特定性别的药物发现的看法。预计这次会议将在以下方面产生新的知识和想法 从分子水平到种群水平性别生物学和医学的重要性，以及 提供了研究它们的方法。它旨在成为一个进程的催化剂，这一进程将导致针对性别的 代谢性疾病的治疗。

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity, organized by Drs. Franck Mauvais-Jarvis, Deborah Clegg and Arthur P. Arnold. The meeting will be held in Tahoe City, California from February 19-22, 2017. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is the generation of data that risks being relevant to only half of the population. This is a timely moment to study sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. The goal of this conference is to fill a need in the scientific community by connecting interdisciplinary groups of scientists who normally would not have an opportunity to interact. This group includes investigators studying sex differences, the role of sex hormones, the systems biology of sex and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. Leaders of the pharmaceutical industry will present their views on sex-specific drug discovery. The meeting is expected to generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level, and to provide the methods to study them. It is intended to be a catalyst of a process that will lead to gender-specific treatments of metabolic diseases.