Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

2007年，调查组发表了一篇论文，以同行评议的形式分享这项研究的概念框架所依据的集体理想(见参考文献)。本文详细介绍了AGEs研究的理论基础、设计、从中年队列先前调查中选取的结果，以及未来的分析计划。 在年龄队列中，我们发现485人(11.5%)有脑微出血的证据；192人有多发性微出血。有视网膜微血管病变迹象的人比没有视网膜微血管病变的人更有可能出现多发性脑微出血。视网膜微血管异常和脑内微出血可能同时发生在老年人，特别是糖尿病患者。 2007年底开始对该队列中的4,000名老年人进行后续检查。 有关这项研究的更多信息，请访问http://www.hjarta.is/english/ages 另见Z01 AG007380(哈里斯博士)。

In 2007 the investigative team published a paper to share, in a peer-review format, the collective idease underlying the conceptual framework for the study (see bibliography). This paper presents, in great detail, the rationale for the AGES study, its design, select findings from previous investigations in the cohort during mid-life, and future analytic plans. In the AGES cohort we found evidence of brain microbleeds was found in 485 (11.5%) people; 192 people had multiple microbleeds. People with signs of retinal microvascular lesions were significantly more likely to have multiple cerbral microbleeds than were people without retinal microvascular lesions. Retinal microvascular abnormalities and microbleeds in the brain microbleeds may occur together in older adults, particularly in people with diabetes. A follow-up examination on a subset of 4,000 elderly individuals in this cohort was initiated at the end of 2007. For more information on the study, see http://www.hjarta.is/english/ages See also Z01 AG007380 (Dr. Harris).