Immunologic Memory and Host Defense

描述（由申请人提供）： 这项建议是为了请求支持一个由斯蒂芬·P·舍恩伯格和苏珊·M·金组织的题为“免疫记忆和宿主防御”的基石研讨会。Kaech，将于2009年2月8日至13日在科罗拉多的Keystone举行。免疫记忆在介导对感染的保护以及增强某些过敏性和自身免疫性疾病中具有关键作用。因此，对适应性免疫记忆调控的细胞和分子机制的深入了解将具有重要的临床应用价值。在这方面，在理解先天免疫应答如何影响适应性免疫方面已经取得了很大进展。此外，改进的方法来可视化体内免疫应答，表征适应性免疫应答的表型和功能特性，以及淋巴和非淋巴区室如何影响这种应答的维持，大大提高了我们在这一领域的理解。然而，主要的障碍仍然涉及在引发足以介导当前疫苗在人类中的保护的持续T细胞应答方面的困难。会议的目标将集中在T和B细胞如何编程以诱导和维持免疫力的基本机制。该计划旨在整合来自小鼠，非人灵长类动物和人类研究的信息，以涵盖与记忆T和B细胞反应控制相关的所有相关领域。总之，这次会议应该促进转化研究，这将影响传染病，癌症，自身免疫性和过敏性疾病的疫苗和干预措施。本次Keystone研讨会会议将重点讨论T和B细胞如何编程以产生和维持免疫力的基本机制。对免疫反应如何诱导和维持的更好理解为疫苗如何发挥作用提供了根本基础，并最终导致疫苗设计的更合理方法。

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "Immunologic Memory and Host Defense", organized by Stephen P. Schoenberger and Susan M. Kaech, which will be held in Keystone, Colorado from February 8 - 13, 2009. Immune memory has a critical role in mediating protection against infections as well as potentiating certain allergic and autoimmune diseases. Hence a thorough understanding of the cellular and molecular mechanisms regulating adaptive immune memory will have important clinical application. In this regard, there has been great progress in understanding how the innate immune response influences adaptive immunity. Furthermore, improved methods to visualize immune responses in vivo, characterize the phenotypic and functional properties of adaptive immune responses and how lymphoid and non-lymphoid compartments influence the maintenance of such responses has substantially improved our understanding in this area. However, major hurdles still relate to difficulties in eliciting sustained T cell responses sufficient to mediate protection in humans with current vaccines. The goal of the meeting will be to focus on basic mechanisms for how T and B cells are programmed to induce and sustain immunity. The program is designed to integrate information from mouse, non-human primate and human studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should facilitate translational research that will impact vaccines and interventions for infectious disease, cancer, and autoimmune and allergic disease. This Keystone Symposia meeting will focus on the basic mechanisms of how T and B cells are programmed to generate and sustain immunity. Improved understanding of how immune responses are induced and maintained provides the fundamental basis for how vaccines work and will ultimately lead to more rational approaches to vaccine design.