Myeloid Cell Diversity: From Fundamental Biology to Disease States

摘要 请求支助题为“骨髓样细胞：机制、多样性和 活动由安德烈·S·伊达尔戈博士、丹妮拉·奎尔和赖冠吴博士组织。会议将在#年举行 加拿大班夫，2024年1月28日至31日。 髓系细胞是先天免疫系统的主要组成部分，是炎症的第一反应者。 这些信号对进行持久的适应性免疫反应至关重要。理解基础生物学 在稳定状态和炎症环境中控制髓系发育和功能是当务之急 开发抗击癌症、心血管疾病、神经变性和其他疾病的治疗方法。使用 随着单细胞技术的使用日益增多，髓系多样性和异质性的巨大范围正在被 首次亮相，围绕健康和健康中的髓系功能状态创造了新的知识空白 疾病。本次Keystone研讨会将探讨变革性的研究概念， 关于髓系生物学的最新观点。会议计划旨在利用尖端成像技术 了解跨组织环境中的髓系先天免疫功能的技术。它还将促进 讨论将重新评估在稳定状态和 炎症，以及挑战我们如何定义髓系细胞亚群与功能性的现有概念 各州。该计划还将包括考虑受过训练的免疫力或生活方式对 健康和疾病中的髓系状态，并讨论髓系细胞代谢调节的新概念 疾病和衰老。与会者将了解可用于研究多样性的新工具和资源 并将面临挑战，重新思考现有的教条，即 低估了髓系细胞对健康和疾病的贡献。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Mechanisms, Diversity and Function, organized by Drs. Andrés Hidalgo, Daniela Quail and Lai Guan Ng. The conference will be held in Banff, Canada from January 28-31, 2024. Myeloid cells are major components of the innate immune system that are first responders to inflammatory cues and critical to engage long-lasting adaptive immune responses. Understanding the fundamental biology governing myeloid development and function in steady-state and inflammatory contexts is imperative to developing treatments to combat cancer, cardiovascular disease, neurodegeneration and other diseases. With the rising use of single cell technologies, the vast extent of myeloid diversity and heterogeneity is being unveiled for the first time, creating new knowledge gaps surrounding myeloid functional states in health and disease. This Keystone Symposia conference will explore transformative research concepts that challenge current views of myeloid biology. The conference program was designed to leverage cutting-edge imaging technologies to learn about myeloid innate immune functions across tissue environments. It will also promote discussions that will reevaluate the fundamental biology underlying myeloid development in steady-state and inflammation, as well as challenge current concepts of how we define myeloid cell subsets versus functional states. The program will also include sessions that will consider the impact of trained immunity or lifestyle on myeloid states in health and disease and discuss emerging concepts in metabolic regulation of myeloid cells in disease and aging. Attendees will learn about new tools and resources that are available to study the diversity of myeloid states in various experimental contexts and will be challenged to rethink existing dogma that underestimates the breadth of myeloid cell contributions to health and disease.