Immunologic Memory, Persisting Microbes and Chronic Disease

描述（由申请人提供）： 该提案请求支持由E。约翰Wherry，巴厘Pulendran和Yasmine Belkaid，这将是在班夫，阿尔伯塔，加拿大从2011年2月6日至11日举行。本次会议的主题是了解免疫记忆如何发展以及这种发展如何受到我们周围和体内微生物世界的影响。免疫记忆可以提供对传染病的有效保护。许多感染被免疫系统迅速清除，给宿主留下保护性的B和T细胞记忆。然而，其他宿主-病原体相互作用是长期的，可以发展成慢性疾病。免疫记忆在这些长期感染期间以不同的方式发展。长期的宿主-病原体相互作用、慢性感染和多种病原体的共感染可以以仍然不完全理解的方式影响宿主的免疫系统。此外，与我们的免疫系统相互作用的微生物不仅包括病原体，还包括正常的细菌和病毒肠道植物群。这些微生物对免疫记忆的影响才刚刚开始评估。本次会议的目标是讨论：1）关于最佳免疫记忆机制的前沿研究; 2）长时间宿主-微生物相互作用对免疫记忆的影响;以及3）如何应用前沿方法研究这些问题可以帮助产生更好的疫苗和免疫疗法。 项目叙述： 免疫记忆可以提供对传染病的有效保护。了解如何通过疫苗接种和其他治疗干预诱导最佳免疫应答，对于治疗和/或预防病毒、细菌和寄生虫感染、癌症和其他疾病具有巨大的潜力。关于免疫记忆，持久性微生物和慢性病的Keystone研讨会会议的重点是了解免疫记忆如何发展以及这种发展如何受到我们周围和内部微生物世界的影响。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Immunologic Memory, Persisting Microbes and Chronic Disease, organized by E. John Wherry, Bali Pulendran and Yasmine Belkaid, which will be held in Banff, Alberta, Canada from February 6-11, 2011. This meeting is focused on the overall theme of understanding how immunological memory develops and how this development is influenced by the microbial world around and within us. Immunological memory can provide potent protection from infectious disease. Many infections are cleared rapidly by the immune system leaving the host with protective B and T cell memory. However, other host-pathogen interactions are long-term and can develop into chronic diseases. Immunological memory develops differently during these protracted infections. Prolonged host-pathogen interactions, chronic infections and co-infection with multiple pathogens can impact the host's immune system in ways that remain incompletely understood. Moreover, the universe of microorganisms with which our immune system interacts includes not only pathogens, but also normal bacterial and viral commensal flora. The impact of these microorganisms on immunological memory is only just starting to be evaluated. The goals of this meeting are to discuss: 1) cutting-edge research on the mechanisms of optimal immunological memory; 2) the impact of prolonged host-microbe interactions on immunological memory; and 3) how the application of cutting-edge approaches to studying these issues can help generate better vaccines and immunotherapies. Project Narrative: Immunological memory can provide potent protection from infectious disease. Understanding how to induce optimal immune responses through vaccination and other therapeutic interventions holds tremendous potential for treating and/or preventing viral, bacterial and parasitic infections, cancer and other diseases. The Keystone Symposia meeting on Immunologic Memory, Persisting Microbes and Chronic Disease is focused on the overall theme of understanding how immunological memory develops and how this development is influenced by the microbial world around and within us.