课题基金 / 基金详情

Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.

Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
保护屏障:钙粘蛋白信号如何协调上皮细胞中的动态粘附和紧密连接组装。
批准号:
nhmrc : 511156
负责人:
Prof Alpha Yap
金额:
$37.2万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

项目成果

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中文摘要
翻译
上皮细胞保护身体免受环境的侵害。在烧伤和炎症中,皮肤和肠道等组织的上皮屏障被破坏,会导致细菌入侵和严重的代谢紊乱。在这个项目中,我们研究细胞信号传导机制,维持上皮屏障在健康组织中进行转换和重塑。了解这些信号通路为理解它们如何在疾病中受到干扰提供了基础。
英文摘要
Epithelia protect the body from its environment. Breakdown of the epithelial barrier in tissues such as the skin and intestine, as occurs in burns and inflammation, leads to invasion of bacteria and severe metabolic disturbances. In this project we study the cell signaling mechanisms that maintain epithelial barriers in healthy tissues that undergo turnover and remodelling. Understanding these signaling pathways provides a foundation to understand how they are perturbed in disease.
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Forces in Nature: Tissue mechanics and cell sociology
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Keeping forces local for epithelial homeostasis
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RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
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How caveolae condition tissue mechanics for an anti-tumor niche.
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  • 财政年份:
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  • 依托单位:
海外基金