Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
批准号:
nhmrc : 511156
负责人:
Prof Alpha Yap
金额:
$37.2万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
上皮细胞保护身体免受环境的侵害。在烧伤和炎症中,皮肤和肠道等组织的上皮屏障被破坏,会导致细菌入侵和严重的代谢紊乱。在这个项目中,我们研究细胞信号传导机制,维持上皮屏障在健康组织中进行转换和重塑。了解这些信号通路为理解它们如何在疾病中受到干扰提供了基础。
英文摘要
Epithelia protect the body from its environment. Breakdown of the epithelial barrier in tissues such as the skin and intestine, as occurs in burns and inflammation, leads to invasion of bacteria and severe metabolic disturbances. In this project we study the cell signaling mechanisms that maintain epithelial barriers in healthy tissues that undergo turnover and remodelling. Understanding these signaling pathways provides a foundation to understand how they are perturbed in disease.
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会议论文
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依托单位:
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财政年份:2018
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How caveolae condition tissue mechanics for an anti-tumor niche.
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批准号:nhmrc : GNT1140090
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财政年份:2018
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依托单位:
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财政年份:2018
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依托单位:
A mechanotransduction apparatus to coordinate epithelial collective cell migration.
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批准号:nhmrc : 1123816
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资助金额:$67.95万
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财政年份:2017
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负责人:Prof Alpha Yap
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依托单位:
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资助金额:$31.22万
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财政年份:2015
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负责人:Prof Alpha Yap
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依托单位:
Cadherin Biology in Morphogenesis and Disease
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批准号:nhmrc : 1044041
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资助金额:$50.13万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
The Plasma membrane in health and disease
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
Program in Membrane Interface Biology
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资助金额:$498.05万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
Mechanotransduction: a new paradigm for cadherin junction biology
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批准号:DP120104667
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资助金额:$25.78万
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财政年份:2012
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负责人:Prof Alpha Yap
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依托单位:
Cortactin: integrating cadherin signalling for junctional integrity
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财政年份:2011
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 631383
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资助金额:$25.67万
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财政年份:2010
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依托单位:
Myosin VI: a novel molecular apparatus for epithelial cohesion
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财政年份:2010
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Actin cytoskeleton regulation by E-cadherin and Src.
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Regulation of Myosin II by E-cadherin adhesion.
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财政年份:2008
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依托单位:
Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases
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批准号:nhmrc : 455824
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资助金额:$35.31万
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财政年份:2007
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负责人:Prof Alpha Yap
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依托单位:
Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins
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资助金额:$17.6万
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财政年份:2006
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依托单位:
海外基金