Solid-state nanopores: tools for single-molecule biophysics

这项研究计划致力于开发新的技术和方法，使用纳米级设备操纵和表征单分子，揭开支配生物分子在纳米限制几何图形中行为的基本物理，并将这些发现转化为生命科学的新工具。虽然这项研究计划是由探索独特的检测和驱动模式推动的，但在纳米尺度的流体环境中对单个分子的操纵和表征(I)代表了一个重要的、基本上未知的领域，在这个领域中，有趣的新物理可以主导和(Ii)以非凡的灵敏度和速度实现对生物分子结构和行为的新的定量测量。因此，该计划将为HQP提供从物理到分子生物学的广泛技术和概念方面的强大、多学科培训。这项研究计划将为HQP提供一个独特的机会，获得宝贵的技术和科学技能，促进他们过渡到生物物理和生物技术领域的未来研究和技术开发环境。

This research program is dedicated to the development of novel techniques and methods to manipulate and characterize single-molecules using nanoscale devices, to unravel the basic physics governing the behaviour of biological molecules in nanoconfined geometries, and to translate these discoveries into new tools for the life sciences. While this research program is driven by the exploration of unique detection and actuation modalities, the manipulation and characterization of individual molecules within nanoscale fluidic environments (i) represents an important and largely uncharted regime in which interesting new physics can dominate and (ii) enables new quantitative measurements, with exceptional sensitivity and speed, on the structure and behavior of biological molecules. As such this program will provide HQP with strong, multidisciplinary training in a broad range of techniques and concepts from physics to molecular biology. This research program will offer a unique opportunity for HQP to acquire valuable technical and scientific skills facilitating their transition to tomorrow's research and technology development environments in the fields of biophysics and biotechnologies.