Solid-state nanopores: tools for single-molecule biophysics

该研究项目致力于开发利用纳米设备操纵和表征单分子的新技术和方法，揭示纳米限制几何中生物分子行为的基本物理规律，并将这些发现转化为生命科学的新工具。虽然这个研究项目是由探索独特的检测和驱动模式驱动的，但在纳米级流体环境中对单个分子的操作和表征(1)代表了一个重要的、很大程度上未知的机制，在这个机制中，有趣的新物理学可以占主导地位；(2)以非凡的灵敏度和速度，对生物分子的结构和行为进行新的定量测量。因此，该项目将为HQP提供强大的多学科培训，涵盖从物理学到分子生物学的广泛技术和概念。这项研究计划将为HQP提供一个独特的机会，以获得有价值的技术和科学技能，促进他们在生物物理学和生物技术领域向未来的研究和技术开发环境过渡。

This research program is dedicated to the development of novel techniques and methods to manipulate and characterize single-molecules using nanoscale devices, to unravel the basic physics governing the behaviour of biological molecules in nanoconfined geometries, and to translate these discoveries into new tools for the life sciences. While this research program is driven by the exploration of unique detection and actuation modalities, the manipulation and characterization of individual molecules within nanoscale fluidic environments (i) represents an important and largely uncharted regime in which interesting new physics can dominate and (ii) enables new quantitative measurements, with exceptional sensitivity and speed, on the structure and behavior of biological molecules. As such this program will provide HQP with strong, multidisciplinary training in a broad range of techniques and concepts from physics to molecular biology. This research program will offer a unique opportunity for HQP to acquire valuable technical and scientific skills facilitating their transition to tomorrow's research and technology development environments in the fields of biophysics and biotechnologies.