Forces in Nature: Tissue mechanics and cell sociology
Forces in Nature: Tissue mechanics and cell sociology
批准号:
FL230100100
负责人:
Prof Alpha Yap
金额:
$226.26万
依托单位国家:
澳大利亚
项目类别:
Australian Laureate Fellowships
财政年份:
2024
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2024-01-01 至 2028-12-31
中文摘要
上皮细胞覆盖在身体表面,形成保护我们免受环境影响的屏障。尽管它们很重要,但我们对细胞如何交流知之甚少。该项目旨在测试上皮细胞通过传输和检测机械力进行通信的新概念,使用细胞和生物物理实验以及物理理论的创新组合。预期的成果是新知识、对青年科学家的跨学科培训、新的国家研究能力和不断增长的国际合作。其好处包括加强澳大利亚的科学联系和研究能力,并提供可能导致生物工程和药物发现方面未来进步的基本知识。
英文摘要
Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia’s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Keeping forces local for epithelial homeostasis
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批准号:DP220103951
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项目类别:Discovery Projects
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资助金额:$41.1万
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财政年份:2022
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负责人:Prof Alpha Yap
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依托单位:
RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
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批准号:DP190102871
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项目类别:Discovery Projects
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资助金额:$52.78万
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财政年份:2019
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负责人:Prof Alpha Yap
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依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
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批准号:nhmrc : 1140090
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项目类别:Project Grants
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资助金额:$73.78万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
Mechanobiology of epithelial homeostasis in health and disease
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批准号:nhmrc : GNT1136592
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项目类别:Research Fellowships
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资助金额:$87.6万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
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批准号:nhmrc : GNT1140090
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项目类别:Project Grants
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资助金额:$109.12万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
Mechanobiology of epithelial homeostasis in health and disease
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批准号:nhmrc : 1136592
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项目类别:Research Fellowships
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资助金额:$59.23万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
A mechanotransduction apparatus to coordinate epithelial collective cell migration.
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批准号:nhmrc : 1123816
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项目类别:Project Grants
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资助金额:$67.95万
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财政年份:2017
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负责人:Prof Alpha Yap
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依托单位:
Tissue tension homeostasis by junctional mechanosensing.
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批准号:DP150101367
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项目类别:Discovery Projects
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资助金额:$31.22万
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财政年份:2015
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负责人:Prof Alpha Yap
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依托单位:
Cadherin Biology in Morphogenesis and Disease
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批准号:nhmrc : 1044041
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项目类别:Research Fellowships
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资助金额:$50.13万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
The Plasma membrane in health and disease
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批准号:nhmrc : GNT1037320
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项目类别:Programs
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资助金额:$473.47万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
Program in Membrane Interface Biology
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批准号:nhmrc : 1037320
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项目类别:Program Grants
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资助金额:$498.05万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
Mechanotransduction: a new paradigm for cadherin junction biology
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批准号:DP120104667
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项目类别:Discovery Projects
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资助金额:$25.78万
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财政年份:2012
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负责人:Prof Alpha Yap
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依托单位:
Cortactin: integrating cadherin signalling for junctional integrity
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批准号:nhmrc : 1010489
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项目类别:NHMRC Project Grants
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资助金额:$39.6万
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财政年份:2011
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负责人:Prof Alpha Yap
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 631383
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项目类别:NHMRC Research Fellowships
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资助金额:$25.67万
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财政年份:2010
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负责人:Prof Alpha Yap
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依托单位:
Myosin VI: a novel molecular apparatus for epithelial cohesion
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批准号:nhmrc : 631377
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项目类别:NHMRC Project Grants
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资助金额:$40.35万
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财政年份:2010
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负责人:Prof Alpha Yap
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依托单位:
Actin cytoskeleton regulation by E-cadherin and Src.
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批准号:DP0988935
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项目类别:Discovery Projects
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资助金额:$20.8万
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财政年份:2009
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负责人:Prof Alpha Yap
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依托单位:
Regulation of Myosin II by E-cadherin adhesion.
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批准号:nhmrc : 511155
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项目类别:NHMRC Project Grants
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资助金额:$38.24万
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财政年份:2008
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负责人:Prof Alpha Yap
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依托单位:
Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
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批准号:nhmrc : 511156
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项目类别:NHMRC Project Grants
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资助金额:$37.2万
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财政年份:2008
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负责人:Prof Alpha Yap
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依托单位:
Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases
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批准号:nhmrc : 455824
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项目类别:NHMRC Project Grants
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资助金额:$35.31万
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财政年份:2007
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负责人:Prof Alpha Yap
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依托单位:
Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins
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批准号:DP0664395
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项目类别:Discovery Projects
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资助金额:$17.6万
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财政年份:2006
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负责人:Prof Alpha Yap
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依托单位:
海外基金